质量水平
检测方案
≥98% (HPLC)
形式
solid
储存条件
protect from light
颜色
off-white to gray-pink
溶解性
DMSO: >10 mg/mL
运输
wet ice
储存温度
−20°C
InChI
1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
InChI key
YMFNPBSZFWXMAD-UHFFFAOYSA-N
应用
JSH-23 已被用作一种核因子 κB（NF-κB）p65 抑制剂。
生化/生理作用
JSH-23 是一种 NF-κB 核易位抑制剂。EMSA 和蛋白质印迹分析表明，它抑制 LPS 和细胞因子诱导的 NF-kB p65 亚基的核易位过程。该化合物具有适度的抑制活性（RAW 264.7 细胞中 IC50 值为 7.1 uM），但不影响 IkB 降解或恢复。该化合物以剂量依赖性方式抑制 LPS 诱导的细胞因子、COX2 和 iNOS 的表达，并且可能结合或干扰 p65 的和定位信号（NLS）。
其他说明
光和空气敏感。
WGK
WGK 3
L Shi et al.
Oncogene, 36(12), 1631-1643 (2016-11-22)
The coordination between cellular differentiation and the mesenchymal/stem transition is essential for both embryo development and neoplasia, suggesting a mechanistic link between these two major processes. In this work we show that miR-127, an embryo-expressing lung miRNA, was prominently induced
HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-?B pathway in acute glaucoma.
Chi W et al.
Journal of Neuroinflammation, 12, 137-137 (2015)
Macrophage TCF-4 co-activates p65 to potentiate chronic inflammation and insulin resistance in mice.
Xia Kang et al.
Clinical science (London, England : 1979), 130(14), 1257-1268 (2016-04-30)
Transcription factor 4 (TCF-4) was recently identified as a candidate gene for the cause of type 2 diabetes, although the mechanisms have not been fully elucidated. In the present study, we demonstrated that the TCF-4 transgene in macrophages aggravated high-fat diet
Macrophage TCF-4 co-activates p65 to potentiate chronic inflammation and insulin resistance in mice.
Kang X et al.
Clinical Science (London, England : 1979), 130, 1257-1257 (2016)
Xiaoyu Cheng et al.
Aging, 12(18), 17976-17989 (2020-09-23)
Serum uric acid is reportedly associated with thrombosis development. However, still unclear is the mechanism of high uric acid in thrombosis with the involvement of let-7c. In an aim to fill this void, we conducted this study by treating mice
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