I9890
m-碘苄胍 半硫酸盐
≥98% (HPLC and TLC), ADP ribosylation inhibitor
别名:
MIBG
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关于此项目
线性分子式:
C8H10IN3 · 1/2H2SO4
化学文摘社编号:
分子量:
324.13
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
m-碘苄胍 半硫酸盐, ≥98% (HPLC and TLC)
SMILES string
OS(O)(=O)=O.NC(=N)NCc1cccc(I)c1.NC(=N)NCc2cccc(I)c2
InChI
1S/2C8H10IN3.H2O4S/c2*9-7-3-1-2-6(4-7)5-12-8(10)11;1-5(2,3)4/h2*1-4H,5H2,(H4,10,11,12);(H2,1,2,3,4)
InChI key
XNACDNPGABUBFR-UHFFFAOYSA-N
assay
≥98% (HPLC and TLC)
impurities
<0.5% Free iodobenzylamine
storage temp.
2-8°C
Quality Level
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Biochem/physiol Actions
一种抑制ADP核糖基化的抗肿瘤药。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Steven G DuBois et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(12), 2715-2721 (2015-02-20)
(131)I-metaiodobenzylguanidine (MIBG) is a radiopharmaceutical with activity in neuroblastoma. Vorinostat is a histone deacetylase inhibitor that has radiosensitizing properties. The goal of this phase I study was to determine the MTDs of vorinostat and MIBG in combination. Patients ≤ 30
C Loesberg et al.
Biochimica et biophysica acta, 1037(1), 92-99 (1990-01-19)
Meta-iodobenzylguanidine (MIBG) is a guanidine analogue of the neurotransmitter norepinephrine. Radioiodinated [131I]MIBG is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. Moreover, non-radiolabelled MIBG exerts several cell-biological effects, tentatively ascribed to interference with cellular
Sylvie Slaets et al.
International journal of geriatric psychiatry, 30(8), 864-869 (2014-11-05)
Iodine-123 metaiodobenzylguanidine (MIBG) cardiac scintigraphy has shown the potential to discriminate dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). However, these studies did not reflect clinical practice, as patients with ischemic heart disease, heart failure, diabetes mellitus, arterial hypertension
Yunlong Zan et al.
Molecular imaging, 14, 373-384 (2015-07-15)
The objective of this work was to evaluate the sympathetic nervous system and structure remodeling during the progression of heart failure in a rodent model using dynamic cardiac single-photon emission computed tomography (SPECT). The spontaneously hypertensive rat (SHR) model was
Adrien Lebasnier et al.
European journal of nuclear medicine and molecular imaging, 42(7), 1043-1051 (2015-01-30)
The aim of this study was to determine the potential diagnostic value of regional myocardial adrenergic (123)I-metaiodobenzylguanidine (MIBG) single photon emission computed tomography (SPECT) imaging to identify patients with Lewy body diseases (LBD+). Sixty-four consecutive patients who underwent cardiac (123)I-MIBG
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