生物来源
rat
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
3D10, monoclonal
形式
buffered aqueous solution
分子量
antigen ~60 kDa
种属反应性
mouse, hamster, bovine, canine, rat, human, monkey
技术
microarray: suitable
western blot: 2-4 μg/mL using HeLa cell extract
同位素/亚型
IgG2a
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... KPNA4(3840)
mouse ... Kpna4(16649)
rat ... Kpna4(361959)
免疫原
recombinant mouse importin α3/Qip1.
生化/生理作用
The gene KPNA4 (karyopherin subunit α 4) encodes a 16kDa protein, also referred to as importin α 3 belonging to the family of karyopherins (designated KPNA1 to KPNA4), that participates in the recognition of NLS (nuclear localization signal) sites and dock NLS-containing proteins destined for transport into the nuclear pore complex. It binds to translocon and participates in the sorting of INM (inner nuclear membrane)-directed integral membrane proteins. It associates with nucleoporins and functions in cargo-translocation across the nuclear membrane.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
KPNA4 Mediates Vitamin D-Dependent Inhibition of NF-kB Activity in Swine Epicardial Preadipocytes.
Chen S
Circulation, A12818-A12818 (2014)
Matthew Frieman et al.
Journal of virology, 81(18), 9812-9824 (2007-06-29)
The host innate immune response is an important deterrent of severe viral infection in humans and animals. Nuclear import factors function as key gatekeepers that regulate the transport of innate immune regulatory cargo to the nucleus of cells to activate
Sharon C Braunagel et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(22), 9307-9312 (2007-05-23)
Spodoptera frugiperda (Sf9) importin-alpha-16 is a translocon-associated protein that participates in the early sorting pathway of baculovirus integral membrane proteins destined for the inner nuclear membrane (INM). To discern whether sorting intermediate protein complexes like those observed in insect cells
Annett Koch et al.
Cell cycle (Georgetown, Tex.), 10(8), 1200-1207 (2011-03-18)
It is well established that mutual relations exist between the oxidative status of a cell and the ubiquitin proteasome system (UPS). Oxidation of proteins leads to misfolding and thus claims a higher proteolytic activity of the UPS to dispose these
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