所有图片(4)
经验公式（希尔记法）:
C41H72O9
CAS号:
分子量:
709.00
Beilstein:
3642126
MDL编号:
UNSPSC代码:
51101500
PubChem化学物质编号:
NACRES:
NA.85
推荐产品
生物来源
Streptomyces conglobatus
质量水平
检测方案
≥98% (HPLC)
溶解性
acetonitrile: 10 mg/mL
抗生素抗菌谱
Gram-positive bacteria
作用机制
cell membrane | interferes
储存温度
−20°C
SMILES字符串
C[C@H](CCC(O)=O)C[C@H](C)C[C@H](C)C(=O)\C=C(/O)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@](C)(O1)[C@H]2CC[C@](C)(O2)[C@@H](C)O
InChI
1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1
InChI key
PGHMRUGBZOYCAA-ADZNBVRBSA-N
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相关类别
应用
来自球状链霉菌的离子霉素已用于：
- 镁离子霉素处理实验
- 无钙Dulbecco′修饰Eagle培养基（DMEM）的补充剂进行离子载体处理
- 外周血单核细胞（PBMC）的再刺激，以利用流式细胞术（FCM）分析细胞因子的产生
- 一种钙离子载体，用于处理卵母细胞，以结合辅助卵母细胞激活（AOA）进行卵胞浆内单精子注射（ICSI）
生化/生理作用
离子霉素对二价阳离子具有高度特异性。它可能对人膀胱癌细胞系有体外和体内的抗增殖作用。离子霉素作为一种细胞凋亡诱导剂，据认为其作用是通过激活潜在的钙反应性内切酶来实现。
离子霉素是一种聚醚抗生素，它是由链霉菌产生的离子载体。这种Ca2+离子载体是比A23187更有效的Ca2+移动离子载体。 它是非荧光的。 它诱导胚胎皮质神经元的凋亡性退化。研究表明，离子霉素可诱导中央脱髓鞘，抑制肾上腺牛 TREK-1 通道，并调节成熟的人 B 细胞的细胞分裂。用于研究钙通量对内质网（ER）应激、线粒体应激和内在细胞凋亡机制的影响。它也与 PMA 一起用于刺激细胞因子、干扰素、穿孔素、白细胞介素2(IL-2) 和 白细胞介素(IL-4) 的细胞内生产。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
Lauren M Sparks et al.
PloS one, 6(7), e21068-e21068 (2011-07-16)
Disturbances in lipid metabolism are strongly associated with insulin resistance and type 2 diabetes (T2D). We hypothesized that activation of cAMP/PKA and calcium signaling pathways in cultured human myotubes would provide further insight into regulation of lipid storage, lipolysis, lipid
Davina Bonte et al.
Fertility and sterility, 112(2), 266-274 (2019-05-28)
To investigate the extent to which assisted oocyte activation (AOA) improves clinical outcomes in patients diagnosed with oocyte activation deficiencies (OADs). Retrospective cohort study comparing AOA cycles and previous intracytoplasmic sperm injection (ICSI) cycles in couples experiencing low or total
Julia Niessl et al.
EBioMedicine, 54, 102727-102727 (2020-04-09)
Untreated HIV infection leads to alterations in HIV-specific CD4+ T cells including increased expression of co-inhibitory receptors (IRs) and skewing toward a T follicular helper cell (Tfh) signature. However, which changes are maintained after suppression of viral replication with antiretroviral
Ye Tian et al.
BMC women's health, 20(1), 246-246 (2020-11-06)
Fertilization failure after intracytoplasmic sperm injection continues to affect couples and the etiology is not well-understood. We characterized a couple with 2-year history of primary unexplained infertility. Three different assisted reproduction attempts (IVF + rescue ICSI, ICSI and ICSI-AOA) showed repeated fertilization
Andrew J M Howden et al.
Nature methods, 10(4), 343-346 (2013-03-12)
Here we demonstrate quantitation of stimuli-induced proteome dynamics in primary cells by combining the power of bio-orthogonal noncanonical amino acid tagging (BONCAT) and stable-isotope labeling of amino acids in cell culture (SILAC). In conjunction with nanoscale liquid chromatography-tandem mass spectrometry
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