I9532
Icilin
≥97% (HPLC), CMR1 receptor agonist, solid
别名:
1-（2-羟基苯基）-4-（3-硝基苯基）-1，2，3，6-四氢嘧啶-2-酮, AG-3-5
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关于此项目
经验公式（希尔记法）:
C16H13N3O4
化学文摘社编号:
分子量:
311.29
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Icilin, ≥97% (HPLC), solid
SMILES string
Oc1ccccc1N2CC=C(NC2=O)c3cccc(c3)[N+]([O-])=O
InChI
1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)
InChI key
RCEFMOGVOYEGJN-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
solid
color
yellow
solubility
DMSO: 15 mg/mL
Quality Level
Application
Icilin已被用作前腹膜内侧前视区（VMPO）神经元的冷却剂。
Biochem/physiol Actions
豌豆球蛋白是CMR1冷和薄荷醇敏感受体的有效激动剂。
General description
Icilin是一种合成的冷却剂，调节人瞬时受体电位阳离子通道（TRPA1）。Icilin抑制瞬时受体电位阳离子通道亚家族M成员8（TRPM8）并调节钙释放。Icilin还抑制瞬时受体电位香草酸亚型3（TRPV3）。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Supercooling agent icilin blocks a warmth-sensing ion channel TRPV3
Sherkheli MA, et al.
TheScientificWorldJournal, 2012(6), 859-869 (2012)
Inhibition of TRPM8 by icilin distinct from desensitization induced by menthol and menthol derivatives
Kuhn FJP, et al.
The Journal of Biological Chemistry, 284(7), 4102-4111 (2009)
Warm-sensitive neurons that control body temperature
Tan CL, et al.
Cell, 167(1), 47-59 (2016)
The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel
Chuang HH, et al.
Neuron, 43(6), 859-869 (2004)
Alexander Lucius et al.
Cellular signalling, 28(3), 136-147 (2015-12-23)
3-Iodothyronamine (3T1AM) is an endogenous thyroid hormone metabolite that interacts with the human trace amine-associated receptor 1 (hTAAR1), a G-protein-coupled receptor, to induce numerous physiological responses including dose-dependent body temperature lowering in rodents. 3T1AM also directly activates cold-sensitive transient receptor
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