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生物来源
human
质量水平
重组
expressed in E. coli
检测方案
≥98% (SDS-PAGE)
形式
lyophilized powder
效能
≤12 pg/mL ED50
质量
endotoxin tested
分子量
17.3 kDa
包装
pkg of 5 and 25 μg
pkg of 25 μg
技术
cell culture | mammalian: suitable
颜色
white to off-white
UniProt登记号
储存温度
−20°C
基因信息
human ... IL1B(3553)
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生化/生理作用
白介素-1 (IL-1)，最初称为淋巴细胞激活因子(LAF)，可激活T细胞淋巴细胞，进而增殖并分泌白介素-2 (IL-2)。IL-1主要从受刺激的巨噬细胞和单核细胞释放，但也已显示可从几种其他类型细胞中释放，并且被认为在炎症和免疫应答中起关键作用。IL-1的其他同义词包括：内源性热原(EP)、有丝分裂原蛋白(MP)、辅助峰-1 (lp -1)、T细胞替代因子III（TRF III或TRFM）、B细胞激活因子(BAF)和B细胞分化因子(BDF)。两种关系紧密的试剂白细胞介素-1 α(IL-1α)和白细胞介素-1β (IL-1β)在氨基酸序列上有62%的同源性，引起几乎相同的生物反应。IL-1α和IL-1β的糖基化量都在17 kDa左右，具有一定的异质性。
外形
从0.2μm过滤的缓冲溶液中冻干。
分析说明
其生物活性是通过鼠D10S细胞对MTS切割的剂量依赖性刺激来进行测定的。
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
Janette Bester et al.
Scientific reports, 6, 32188-32188 (2016-08-27)
Complex interactions exist between cytokines, and the interleukin family plays a fundamental role in inflammation. Particularly circulating IL-1β, IL-6 and IL-8 are unregulated in systemic and chronic inflammatory conditions. Hypercoagulability is an important hallmark of inflammation, and these cytokines are
Seong Soo Joo et al.
Biological & pharmaceutical bulletin, 33(11), 1854-1860 (2010-11-05)
In pancreatic islets, free radical formation produced upon exposure to proinflammatory cytokines mediates β cell destruction, which ultimately leads to type 1 diabetes (T1D). In this study, we examined whether laccase, a family of the blue copper protein, can be
Tanja Mang et al.
International journal of molecular sciences, 21(2) (2020-01-18)
The environment surrounding chondrocytes changes drastically in osteoarthritis (OA). For instance, the osmolarity in cartilage (ranging from 350 to 460 mOsm in healthy tissue) decreases during the progression of OA, reaching 270 mOsm. The objective of this study was to
Nicholas F Lahens et al.
BMC genomics, 18(1), 602-602 (2017-08-12)
Though Illumina has largely dominated the RNA-Seq field, the simultaneous availability of Ion Torrent has left scientists wondering which platform is most effective for differential gene expression (DGE) analysis. Previous investigations of this question have typically used reference samples derived
Charles A Dinarello et al.
Current opinion in endocrinology, diabetes, and obesity, 17(4), 314-321 (2010-07-01)
To understand the role of inflammation as the fundamental cause of type 2 diabetes and specifically to examine the contribution of IL-1beta. Recent studies from animals, in-vitro cultures and clinical trials provide evidence that support a causative role for IL-1beta
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