生物来源
human
质量水平
重组
expressed in E. coli
检测方案
>97% (SDS-PAGE)
形式
lyophilized powder
效能
0.2-4.0 ng/mL EC50
分子量
antigen predicted mol wt ~12.5 kDa
包装
pkg of 5 μg
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
human ... IL15(3600)
相关类别
生化/生理作用
IL-15（白介素15）是一种多效促炎性细胞因子，是先天性和适应性免疫反应之间的连接纽带。它参与各种淋巴细胞谱系的增殖、存活和激活。 IL-15 的作用是与含有IL-15Rα、IL-2/15Rβ 和 IL-Rγ的高亲和力异源三聚体受体复合物结合。和IL-R＆＃947;。它以不同的形式存在，如由 IL-15 受体α 链和可溶的细胞因子结合形成的可溶 Hhyper Il-15，以及膜结合亚型。
白介素-15最先从猴肾脏上皮细胞系的培养上清液中分离取得。 它的cDNA编码162个氨基酸的前体蛋白，其中带有48个氨基酸的信号肽，切除后生成114个氨基酸的成熟蛋白。人IL-15与猴(~97%)和鼠(~73%)IL-15具有序列一致性。IL-15会与IL-2竞争结合位点，因两者均通过IL-2受体刺激细胞生长。
外形
从 pH 7.4 的磷酸盐缓冲盐水中 0.2 µm 过滤溶液冻干所得，每 1 μg 中含 50 μg 牛血清白蛋白作为载体蛋白。
分析说明
使用 Mo7e 人巨核细胞白血病细胞，通过细胞增殖检测进行测定。人重组 IL-15 的比活性约为 4.5 x 105 U/μg——此数值已针对人重组 IL-15 WHO 国际标准（NIBSC 代码：95/554）进行了校准。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
含少量动物源组分生物产品
Hua Wang et al.
Medical oncology (Northwood, London, England), 32(1), 370-370 (2014-11-28)
Interleukin-15 (IL-15) is a proinflammatory cytokine involved in the proliferation, survival, and activation of multiple lymphocyte lineages. However, the prognostic significance of IL-15 for extranodal NK/T cell lymphoma (ENKTL) has not been well established. We retrospectively analyzed 112 patients with
Alicia Santos Savio et al.
BMC musculoskeletal disorders, 16, 51-51 (2015-04-17)
Pro-inflammatory cytokines are directly implicated in the pathogenesis of Rheumatoid arthritis (RA). Variable clinical response to cytokine targeted therapies as TNFalpha and IL-6, strongly highlights the heterogeneity of inflammatory process in RA. Another cytokine, IL-15 has also been related to
Mario Bunse et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(11), 1983-1991 (2014-07-23)
Genetically modified T cells that express a transduced T cell receptor (TCR) α/β heterodimer in addition to their endogenous TCR are used in clinical studies to treat cancer. These cells express two TCR-α and two TCR-β chains that do not
Jianan Zhu et al.
Frontiers in immunology, 13, 813218-813218 (2022-03-01)
Unexplained recurrent spontaneous abortion (URSA) is believed to be associated with impaired immunosuppression at the maternal-fetal interface, but the detailed molecular mechanism remains unclear. The ATP-adenosine metabolic pathway regulated by CD39/CD73 has recently been recognized to be important in immunosuppression.
K H Grabstein et al.
Science (New York, N.Y.), 264(5161), 965-968 (1994-05-13)
A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues
商品
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
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