所有图片(1)
About This Item
经验公式（希尔记法）:
C8H17N3O2 · 2 HCl
CAS号:
分子量:
260.16
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.77
生物来源
synthetic (organic)
检测方案
≥97% (HPLC)
形式
powder
溶解性
water: 50 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
Cl.Cl.CC(=N)NCCCC[C@H](N)C(O)=O
InChI
1S/C8H17N3O2.2ClH/c1-6(9)11-5-3-2-4-7(10)8(12)13;;/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13);2*1H/t7-;;/m0../s1
InChI key
OQIBCXRAFAHXMM-KLXURFKVSA-N
基因信息
human ... NOS2(4843)
应用
L-N6-（1-亚氨乙基）赖氨酸二盐酸盐已被用作诱导型一氧化氮合酶（iNOS）抑制剂：
- 研究其对瘦素诱导的小鼠心肌细胞和脂肪细胞中纤维连接蛋白Ⅲ型域包含蛋白五（FNDC5）/鸢尾素的调节作用
- 研究其对瘦素诱导的肝细胞炎症的影响
- 阻断小鼠骨髓间充质基质细胞（BMSCs）中一氧化氮的生成
生化/生理作用
诱导型一氧化氮合酶（iNOS）的选择性抑制剂。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Sara Becerril et al.
Genes, 10(3) (2019-03-02)
iNOS deficiency in ob/ob mice improved liver inflammation and ECM remodeling-related genes, decreasing fibrosis, and metabolic dysfunction. The activation of iNOS by leptin is necessary for the synthesis and secretion of TNC in hepatocytes, suggesting an important role of this
W M Moore et al.
Journal of medicinal chemistry, 37(23), 3886-3888 (1994-11-11)
L-N6-(1-Iminoethyl)lysine (L-NIL) has been synthesized and is shown to be both a potent and selective inhibitor of mouse inducible nitric oxide synthase (miNOS). L-NIL has an IC50 of 3.3 microM for miNOS compared to an IC50 of 92 microM for
Nikolai V Gorbunov et al.
Journal of cellular and molecular medicine, 19(5), 1133-1150 (2015-02-28)
The bone marrow stroma constitutes the marrow-blood barrier, which sustains immunochemical homoeostasis and protection of the haematopoietic tissue in sequelae of systemic bacterial infections. Under these conditions, the bone marrow stromal cells affected by circulating bacterial pathogens shall elicit the
Jérémy Postat et al.
Immunity, 49(4), 654-665 (2018-09-30)
Recruitment of immune cells with antimicrobial activities is essential to fight local infections but has the potential to trigger immunopathology. Whether the immune system has the ability to sense inflammation intensity and self-adjust accordingly to limit tissue damage remains to be
A Rodríguez et al.
International journal of obesity (2005), 39(3), 397-407 (2014-09-10)
BACKGROUND/OBJETIVES: Obese leptin-deficient ob/ob mice exhibit high adiposity and reduced muscle mass with leptin replacement promoting weight loss and inducing muscle accretion through PGC-1α-dependent mechanisms. Our aim was to analyze in vivo and in vitro the effect of leptin on
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