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Merck
CN

I8000

Sigma-Aldrich

2-碘苯甲酸

≥98% (TLC)

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别名:
IBA
线性分子式:
OIC6H4CO2H
CAS号:
分子量:
264.02
Beilstein:
1939973
EC 号:
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26

检测方案

≥98% (TLC)

质量水平

形式

powder

颜色

white to off-white

mp

230 °C (dec.) (lit.)

储存温度

−20°C

SMILES字符串

OC(=O)c1ccccc1[I]=O

InChI

1S/C7H5IO3/c9-7(10)5-3-1-2-4-6(5)8-11/h1-4H,(H,9,10)

InChI key

IFPHDUVGLXEIOQ-UHFFFAOYSA-N

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相关类别

应用

色氨酸肽键断裂。

生化/生理作用

碘苯甲酸 (IBA) 可用于研究酶的结构和活性。IBA 用作氧化剂,氧化邻近巯基为酶内的二硫化物(半胱氨酸残基),导致其失活或构象变化。IBA 也用于裂解色氨酸肽键。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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S P Fling et al.
Current eye research, 7(2), 191-199 (1988-02-01)
Bovine retinal S-antigen was cleaved by three chemical cleavage procedures including o-iodosobenzoic acid (IBA), mile acid and cyanogen bromide. The resultant peptides were used to study antibody-defined epitopes. Treatment with IBA, which cleaves primarily at tryptophanyl peptide bonds, produced at
I Locklear et al.
Neuroscience, 35(3), 707-713 (1990-01-01)
A previously developed model of exercise-induced muscle contracture using iodoacetate to inhibit glyceraldehyde-3-phosphate dehydrogenase in rat hindlimb muscles produced selective type II myofiber damage. Utilizing a modification of the same model system, rats were given intra-aortic ortho-iodosobenzoic acid (700 nmol/kg
Susanne Müller et al.
Toxicology letters, 200(1-2), 53-58 (2010-11-03)
Developing potent detoxification strategies for prophylaxis and therapy against organophosphate (OP) intoxication still represents a challenging task. Clinical application of numerous investigated substances including enzymes and low molecular scavengers like metal ions or nucleophiles could not yet be realised due
R J Duhe et al.
The Journal of biological chemistry, 269(10), 7290-7296 (1994-03-11)
The calmodulin binding domain of the type I adenylyl cyclase has recently been identified as an amino acid sequence (residues 495-522) that contains 2 cysteine residues. Therefore, we examined the effect of several sulfhydryl reagents on the calmodulin sensitivity of
J M Souza et al.
Archives of biochemistry and biophysics, 360(2), 187-194 (1998-12-16)
Rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was inactivated by peroxynitrite under biologically relevant conditions. The decrease of enzymatic activity followed an exponential function, and the concentration of peroxynitrite needed to inactivate 50% of 7 microM GAPDH (IC50) was 17 microM. Hydroxyl

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