I7388
异黄蝶呤
≥97.5%, powder
别名:
2-氨基-4,7-二羟基-1,3,5,8-四氮杂萘, 2-氨基-4,7-二羟基蝶啶, 2-氨基-4,7-蝶啶二醇
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关于此项目
经验公式（希尔记法）:
C6H5N5O2
化学文摘社编号:
分子量:
179.14
UNSPSC Code:
41106305
NACRES:
NA.51
PubChem Substance ID:
EC Number:
208-469-5
Beilstein/REAXYS Number:
181594
MDL number:
InChI key
GLKCOBIIZKYKFN-UHFFFAOYSA-N
InChI
1S/C6H5N5O2/c7-6-10-4-3(5(13)11-6)8-1-2(12)9-4/h1H,(H4,7,9,10,11,12,13)
SMILES string
NC1=NC2=C(N=CC(=O)N2)C(=O)N1
assay
≥97.5%
form
powder
color
off-white
solubility
1 M NaOH: 50 mg/mL, clear, very dark yellow
storage temp.
room temp
Application
Isoxanthopterin is a substrate for the enzyme isoxanthopterin deaminase.
Other Notes
Product of xanthine oxidase oxidation of pterin, an enzyme involved in reactive oxygen formation.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
A Atlante et al.
Brain research. Brain research protocols, 6(1-2), 1-5 (2000-11-22)
Since xanthine oxidase (XO, Xanthine:oxidoreductase, E.C.1.2.3.22) is a key enzyme in reactive oxygen specie formation which plays a major role in cell oxidative stress, the availability of a sensitive and simple assay useful to detect its activity in monolayer cell
I Ziegler
Journal of cellular biochemistry, 28(3), 197-206 (1985-01-01)
After iodine oxidation, biopterin, 6-hydroxymethylpterin, and 6-formylpterin were identified in mouse spleen lymphocytes by means of reverse-phase HPLC, Crithidia assay, and oxidative degradation. Concanavalin A activation induces a 30-fold increase in the pteridine amounts; biopterin as well as the sum
T Yamamoto et al.
Journal of chromatography. B, Biomedical applications, 681(2), 395-400 (1996-06-07)
An assay for human plasma xanthine oxidase activity was developed with pterin as the substrate and the separation of product (isoxanthopterin) by high-performance liquid chromatography with a fluorescence detector. The reaction mixture consists of 60 microliters of plasma and 240
Gabriella Allegri et al.
Bioanalysis, 4(14), 1739-1746 (2012-08-11)
The present work describes an analytical method for urinary pterins by LC-MS/MS, with emphasis on the separation of 6- and 7-positional isomers of bio- and neopterins. Urine sample preparation consisted of oxidation by MnO(2), filtration and direct dilution in the
R Walter et al.
American journal of respiratory and critical care medicine, 156(6), 2006-2010 (1997-12-31)
Pulmonary endothelial dysfunction is the hallmark of acute lung injury. Impaired pulmonary endothelial nitric oxide (NO) production in this event has been described. Tetrahydrobiopterin (BH4) is an essential cofactor for NO synthase and modulator of its activity. At high local
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