Application
吲哚-3-甲醇用于封装聚-乳酸-co-乙醇酸 (PLGA)，以研究其对乳腺腺癌上皮细胞(MCF7)、结肠腺癌上皮细胞(Caco2)、前列腺癌上皮细胞(PC3)的体外抗癌效果。它还被用作细胞色素P4501A (CYP1A)诱导物。
Biochem/physiol Actions
吲哚-3-甲醇(I3C)激活芳烃受体(AhR)，诱导G1细胞周期阻滞和凋亡。因此，它是一种潜在的抗癌剂。此外，它通过刺激细胞色素P450酶来诱导雌二醇代谢。因此，I3C被认为是一种有效的化疗药物，用于各种类型的癌症，包括乳腺癌、前列腺癌、结肠癌和白血病。
在起始阶段抑制致癌症发生。已经证明在几种动物中具有抑制癌症发生的作用，但如果在发病后阶段给药，它会增加肿瘤的发病率。 在十字花科蔬菜中发现。
General description
吲哚-3-甲醇是十字花科蔬菜中产生的一种新的次生植物代谢产物，例如卷心菜、花椰菜和抱子甘蓝等。
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Warning
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Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
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WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Chronic inflammation is an underlying factor in the development and progression of many of the chronic diseases of aging, such as arthritis, atherosclerosis, diabetes, and cancer.
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