所有图片(2)
About This Item
经验公式（希尔记法）:
C35H38Cl2N8O4
CAS号:
分子量:
705.63
MDL编号:
UNSPSC代码:
51102829
PubChem化学物质编号:
NACRES:
NA.85
推荐产品
质量水平
方案
≥98% (HPLC)
颜色
white
溶解性
chloroform: 50 mg/mL, clear, colorless
抗生素抗菌谱
fungi
作用机制
enzyme | inhibits
储存温度
2-8°C
SMILES字符串
CCC(C)N1N=CN(C1=O)c2ccc(cc2)N3CCN(CC3)c4ccc(OCC5COC(Cn6cncn6)(O5)c7ccc(Cl)cc7Cl)cc4
InChI
1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3
InChI key
VHVPQPYKVGDNFY-UHFFFAOYSA-N
正在寻找类似产品? 访问 产品对比指南
相关类别
应用
伊曲康唑是一种三唑类抗真菌药。 用于抑制细胞色素P-450依赖性酶和麦角固醇合成。已用于抗组织胞浆菌病、芽生菌病、隐球菌脑膜炎和曲霉病。 其′不同的制剂用于研究小鼠侵袭性感染中的念珠菌菌株。 它已被用于研究四氧嘧啶诱导的糖尿病的大鼠前胃粘膜的增殖变化。
生化/生理作用
伊曲康唑抑制细胞色素 P-450 依赖性酶，从而抑制麦角固醇的合成。它通过与 14-α 脱甲基酶相互作用来实现该抑制作用，14-α 脱甲基酶是将羊毛甾醇转化为麦角固醇所必需的细胞色素 P-450 酶。麦角固醇是真菌细胞膜的重要组成部分。因此，它的抑制作用导致细胞通透性增加，造成细胞内容物外泄。伊曲康唑还可能抑制内源性呼吸、与膜磷脂相互作用、抑制酵母转化为菌丝体形式、抑制嘌呤摄取，并减少甘油三酸酯和磷脂的生物合成。
合成广谱三唑类抗真菌药。作用方式：抑制细胞色素 P450 依赖性酶，包括 14α-脱甲基酶。抑制作用导致麦角固醇（一种重要的真菌细胞壁成分）的生物合成受到阻止。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Alexis Laurent et al.
Mycoses, 60(9), 581-586 (2017-05-10)
Trichophyton rubrum is the most frequently isolated dermatophyte species in European countries. The lack or poor sporulation of T. rubrum has always been a major complication and a limiting factor when performing antifungal susceptibility testing. Therefore, we describe an in vitro
Katsuhisa Uchida et al.
The Journal of antimicrobial chemotherapy, 66(3), 626-634 (2010-12-22)
To examine whether in vitro antifungal susceptibility test results correlate with in vivo efficacy of two cyclodextrin-solubilized itraconazole formulations (intravenous and oral) against Candida in a murine model of invasive infection. A selected set of 12 Candida spp. strains with
Tomoya Sano et al.
Toxicologic pathology, 37(6), 790-798 (2009-08-25)
Alloxan-induced diabetic rats frequently exhibit proliferative lesions of squamous hyperplasia accompanied by chronic inflammation and Candida albicans infection in the forestomach, and some lesions progress to squamous cell carcinoma (SCC). Candida infection causes not only hyperplastic changes with inflammation but
Prashanth Kumar M Veeresh et al.
Cancers, 15(19) (2023-10-14)
The incidence of aggressive and resistant breast cancers is growing at alarming rates, indicating a necessity to develop better treatment strategies. Recent epidemiological and preclinical studies detected low serum levels of vitamin D in cancer patients, suggesting that vitamin D
Andreana Marino et al.
BMC complementary medicine and therapies, 20(1), 89-89 (2020-03-19)
Hydrolates, complex mixtures containing traces of essential oils (EOs), are inexpensive, easy to make and less toxic than their corresponding EOs. The antibacterial and antifungal activity of the hydrolate of Coridothymus capitatus (L.) Reichenb. fil. (Lamiaceae) alone and in combination with antimicrobial
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门