I6657
伊曲康唑
≥98% (HPLC)
别名:
R51211, 奥立康唑, 孢粉
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经验公式（希尔记法）:
C35H38Cl2N8O4
化学文摘社编号:
分子量:
705.63
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
MDL number:
产品名称
伊曲康唑, ≥98% (HPLC)
InChI
1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3
SMILES string
CCC(C)N1N=CN(C1=O)c2ccc(cc2)N3CCN(CC3)c4ccc(OCC5COC(Cn6cncn6)(O5)c7ccc(Cl)cc7Cl)cc4
InChI key
VHVPQPYKVGDNFY-UHFFFAOYSA-N
assay
≥98% (HPLC)
color
white
solubility
chloroform: 50 mg/mL, clear, colorless
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
storage temp.
2-8°C
Quality Level
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Application
伊曲康唑是一种三唑类抗真菌药。 用于抑制细胞色素P-450依赖性酶和麦角固醇合成。已用于抗组织胞浆菌病、芽生菌病、隐球菌脑膜炎和曲霉病。 其′不同的制剂用于研究小鼠侵袭性感染中的念珠菌菌株。 它已被用于研究四氧嘧啶诱导的糖尿病的大鼠前胃粘膜的增殖变化。
Biochem/physiol Actions
伊曲康唑抑制细胞色素 P-450 依赖性酶，从而抑制麦角固醇的合成。它通过与 14-α 脱甲基酶相互作用来实现该抑制作用，14-α 脱甲基酶是将羊毛甾醇转化为麦角固醇所必需的细胞色素 P-450 酶。麦角固醇是真菌细胞膜的重要组成部分。因此，它的抑制作用导致细胞通透性增加，造成细胞内容物外泄。伊曲康唑还可能抑制内源性呼吸、与膜磷脂相互作用、抑制酵母转化为菌丝体形式、抑制嘌呤摄取，并减少甘油三酸酯和磷脂的生物合成。
合成广谱三唑类抗真菌药。作用方式：抑制细胞色素 P450 依赖性酶，包括 14α-脱甲基酶。抑制作用导致麦角固醇（一种重要的真菌细胞壁成分）的生物合成受到阻止。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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