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Merck
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主要文件

安全信息

I6383

Sigma-Aldrich

氧化胰岛素链 B 来源于牛胰腺

≥80% (HPLC), powder

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About This Item

经验公式（希尔记法）:
C157H232N40O47S2
CAS号:
30003-72-6
分子量:
3495.89
MDL编号:
MFCD00131380
UNSPSC代码:
12352202
NACRES:
NA.77
生物来源:
bovine
表单:
powder
方案:
≥80% (HPLC)

生物来源

bovine

质量水平

200

无菌性

non-sterile

方案

≥80% (HPLC)

表单

powder

分子量

3496 Da by calculation (Average Mass)

UniProt登记号

P01317

运输

ambient

储存温度

−20°C

SMILES字符串

[S](=O)(=O)(O)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc8c

InChI

1S/C157H232N40O47S2/c1-79(2)57-104(181-130(211)86(15)172-136(217)103(50-53-125(209)210)180-152(233)127(84(11)12)194-148(229)107(60-82(7)8)184-145(226)113(67-95-70-165-78-171-95)189-150(231)115(74-198)176-123(206)73-169-133(214)116(75-245(239,240)241)191-140(221)105(58-80(3)4)182-144(225)112(66-94-69-164-77-170-94)188-138(219)102(48-51-119(160)202)178-146(227)114(68-120(161)203)190-153(234)126(83(9)10)193-131(212)98(159)61-89-31-21-18-22-32-89)139(220)185-110(64-92-40-44-96(200)45-41-92)142(223)183-106(59-81(5)6)147(228)195-128(85(13)14)154(235)192-117(76-246(242,243)244)134(215)168-71-121(204)174-101(49-52-124(207)208)137(218)177-99(38-29-55-166-157(162)163)132(213)167-72-122(205)175-108(62-90-33-23-19-24-34-90)141(222)186-109(63-91-35-25-20-26-36-91)143(224)187-111(65-93-42-46-97(201)47-43-93)149(230)196-129(88(17)199)155(236)197-56-30-39-118(197)151(232)179-100(37-27-28-54-158)135(216)173-87(16)156(237)238/h18-26,31-36,40-47,69-70,77-88,98-118,126-129,198-201H,27-30,37-39,48-68,71-76,158-159H2,1-17H3,(H2,160,202)(H2,161,203)(H,164,170)(H,165,171)(H,167,213)(H,168,215)(H,169,214)(H,172,217)(H,173,216)(H,174,204)(H,175,205)(H,176,206)(H,177,218)(H,178,227)(H,179,232)(H,180,233)(H,181,211)(H,182,225)(H,183,223)(H,184,226)(H,185,220)(H,186,222)(H,187,224)(H,188,219)(H,189,231)(H,190,234)(H,191,221)(H,192,235)(H,193,212)(H,194,229)(H,195,228)(H,196,230)(H,207,208)(H,209,210)(H,237,238)(H4,162,163,166)(H,239,240,241)(H,242,243,244)/t86-,87-,88+,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,126-,127-,128-,129-/m0/s1

InChI key

CZJQESISDHGFTC-DQCCOYHDSA-N

基因信息

cow ... INS(280829)

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相关类别

Amino Acid Sequence

Phe-Val-Asn-Gln-His-Leu-Cys(SO3H)-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys(SO3H)-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala

一般描述

Insulin is made up of two polypeptide chains (A and B) linked together by two disulfide linkages. Chain A and B are composed of 21 amino acids and 30 amino acids, respectively.

应用

Insulin Chain B Oxidized from bovine pancreas has been used:
  • as a matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry (MS) calibration standard
  • in electrochemical impedance spectroscopy and quartz crystal nanobalance (EQCN) studies of insulin adsorption on platinum
  • as an internal standard to quantify insulin chain B residue in protein samples

生化/生理作用

胰岛素调节细胞对葡萄糖、氨基酸和脂肪酸的摄取、使用和储存。可抑制糖原、蛋白质和脂肪的降解。β 链是羧肽酶 Y 的底物。

制备说明

制备参照 Sanger, F. 等人的方法并加以改进

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

胰岛素激素类产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000403366
0000416098
0000416098
0000403366
0000364180

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Carol E Parker et al.
Molecular biotechnology, 20(1), 49-62 (2002-03-06)
Proteolytic digestion of proteins bound to immobilized antibodies, combined with matrix assisted laser desorption (MALDI) mass spectrometric identification of the affinity-bound peptides, can be a powerful technique for epitope determination. Binding of the protein to the antibody is done while
L He et al.
Journal of mass spectrometry : JMS, 34(9), 909-914 (1999-09-24)
Matrix-assisted laser desorption/ionization (MALDI) mass spectra were obtained from single particles injected directly into a time-of-flight mass spectrometer. Aerosol particles were generated at atmospheric pressure using a piezoelectric single-particle generator or a pneumatic nebulizer and introduced into the mass spectrometer
Electrochemical impedance spectroscopy and quartz crystal nanobalance (EQCN) studies of insulin adsorption on Pt
Wright JEI, et al.
Journal of Electroanalytical Chemistry, 564, 185-197 (2004)
Fractionation of oxidized insulin.
F Sanger
The Biochemical journal, 44(1), 126-128 (1949-01-01)
Epitope mapping by a combination of epitope excision and MALDI-MS.
C E Parker et al.
Methods in molecular biology (Clifton, N.J.), 146, 185-201 (2000-08-19)
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