所有图片(4)
About This Item
经验公式（希尔记法）:
C4H7NS · HCl
CAS号:
分子量:
137.63
Beilstein:
3620079
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.21
方案:
≥98% (TLC)
表单:
powder
溶解性:
H2O: 100 mg/mL
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一般描述
2-氨基硫代乙烷盐酸盐（2-IT.HCl），一种蛋白质修饰试剂，通常用于将硫醇基团连接到蛋白质和肽上。用 2-IT 修饰的毛发角蛋白纤维的拉曼光谱分析。HCl 显示出新的二硫化物基团的形成。
应用
2-硫代乙烯基盐酸盐已用于合成硫醇化 PEG（聚（乙二醇））。它可用于合成 PLA-SH（聚乙二醇-硫醇）和 PLA-PEG-SH（聚乙二醇-聚乳酸-硫醇）。
伯胺的硫醇化试剂。在 pH 7-10 下，通过脒键反应，得到游离巯基。 可用于制备二硫化物和/或硫醚连接的缀合物。
其他说明
注意：脒键具有初始伯胺的正电荷。包含五个原子的连接臂。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Hafizah Mahmud et al.
International journal of molecular sciences, 19(3) (2018-03-03)
We recently have established a successful xenograft model of human glioblastoma cells by enriching hyaluronic acid-dependent spheroid-forming populations termed U251MG-P1 cells from U251MG cells. Since U251MG-P1 cells have been confirmed to express CD44 along with principal stemness marker genes, OCT3/4
Akio Kuzuhara
Biopolymers, 79(4), 173-184 (2005-09-08)
For the purpose of investigating in detail the influence of chemical modification using 2-iminothiolane hydrochloride (2-IT) on keratin fibers, the structure of cross-sections at various depths of white human hair, treated with 2-IT and then oxidized, was directly analyzed without
Alexander Ewe et al.
Nanomedicine : nanotechnology, biology, and medicine, 13(1), 209-218 (2016-08-25)
Therapeutic applications of RNA interference (RNAi) require efficient siRNA delivery strategies in vivo. Combining lipid-based carriers with polymeric nanoparticles offers the favorable properties of both systems. This is the first study to explore polyethylenimine-based lipopolyplexes comprising a low-molecular weight PEI
Sitah Al Harthi et al.
Scientific reports, 9(1), 9563-9563 (2019-07-04)
This study aims to prepare, characterize and evaluate the pharmacokinetics of liposomal donepezil HCl (LDH) dispersed into thiolated chitosan hydrogel (TCH) in rabbits. Various hydrogels including TCH were prepared, and after characterization, TCH was selected for subsequent evaluations, due to
M J McCall et al.
Bioconjugate chemistry, 1(3), 222-226 (1990-05-01)
A one-step method for conjugating macrocyclic chelators to antibodies using the protein modification reagent 2-iminothiolane controls aggregation, maintains immunoreactivity, and produces consistent chelate/antibody ratios. Conjugation conditions have been investigated with the macrocyclic chelates 6-[p-(bromoacetamido)benzyl]-1,4,8,11-tetraazacyclotetradecane-N,N ',N",N"'-tetraacetic acid and 2-[p-(bromoacetamido)benzyl]-1,4,7,10-tetraazacyclododecane-N,N',N ",N"'-tetraacetic acid
商品
Collagen molecules play a critical role in tissue architecture and strength, and in cell-matrix interactions as insoluble ligands to regulate the diverse phenotypic activities of cells.
Kanjiro Miyata (The University of Tokyo, Japan) provides insights on the rational design of polymeric materials for “smart” oligonucleotide delivery.
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