质量水平
检测方案
≥98% (HPLC)
形式
solid
颜色
off-white to light yellow
溶解性
DMSO: ≥5 mg/mL
储存温度
2-8°C
SMILES字符串
O=C(C1=CC([N+]([O-])=O)=CC=C1)NC2=NC3=C(N2CCN4CCOCC4)C=CC=C3
InChI
1S/C20H21N5O4/c26-19(15-4-3-5-16(14-15)25(27)28)22-20-21-17-6-1-2-7-18(17)24(20)9-8-23-10-12-29-13-11-23/h1-7,14H,8-13H2,(H,21,22,26)
InChI key
QTCFYQHZJIIHBS-UHFFFAOYSA-N
应用
IRAK-1/4抑制剂I已用于各种研究，用于抑制肝癌细胞系和头颈部鳞状细胞癌（HNSCC）细胞系中的IRAK1。
生化/生理作用
IRAK-1/4抑制剂I是一种新型苯并咪唑，且是白细胞介素-1受体相关激酶1/4（IRAK 1/4）的一种有效抑制剂。 对于IRAK-1和-4的IC50值分别为300 nM和200 nM，而对于测试的一组27种其他激酶，IC 50值> 10,000 nM。
IRAK1过度表达会导致头颈部鳞状细胞癌（HNSCC）的发展。因此，IRAK-1/4抑制剂I可能是HNSCC肿瘤的潜在治疗剂。各种实验研究表明，IRAK-1/4抑制剂可能对核因子(NF)-κB信号通路有抑制作用。
WGK
WGK 3
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Federica Agliano et al.
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Sterile stimuli can trigger inflammatory responses, and in some cases can lead to a variety of acute or chronic diseases. In this study, we hypothesize that a benzimidazole inhibitor may be used as a therapeutic in the treatment of sterile inflammation.
The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation.
Yeaton, et al.
Cancer Discovery, 12, 2392-2413 (2023)
Targeting interleukin-1 receptor-associated kinase 1 for human hepatocellular carcinoma
Li N, et al.
Journal of Experimental & Clinical Cancer Research, 35(1), 140-140 (2016)
Mostafa Allahyari et al.
Asian biomedicine : research, reviews and news, 14(6), 253-260 (2020-12-31)
Obesity and the inflammation associated with it, play a key role in the development of insulin resistance through the release of inflammatory cytokines and free fatty acids and the stimulation of toll-like receptors (TLR). Interleukin-1 receptor-associated kinase (IRAK), which mediates
IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival
Adams AK, et al.
Oncotarget, 6(41), 43395-43395 (2015)
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