推荐产品
生物来源
human
质量水平
重组
expressed in E. coli
检测方案
≥95%
形式
buffered aqueous solution
分子量
19 kDa
包装
pkg of 100K units
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
颜色
colorless
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... IFNA2(3440)
相关类别
应用
已使用人干扰素-αA/D：
- 用于鉴定冠状病毒复制酶抑制剂
- 与ACH-806[1-（4-戊氧基-3-三氟甲基苯基）-3-（吡啶-3-羰基）硫脲]结合以研究对丙型肝炎病毒（HCV）复制的影响
- 与维生素D结合用于检查细胞培养物中HCV蛋白生成的减少
生化/生理作用
干扰素-αA/D（Bg/II），也称为通用I型干扰素，是一种跨越物种屏障的α干扰素杂种。Bg/II表示由重组人干扰素αA和αD构建该杂种的限制性酶切位点。干扰素-αA/D 已被证明对许多哺乳动物细胞具有活性。它可以替代人，猴，小鼠，牛，大鼠，猫，狗，兔，绵羊，山羊，马，猪或仓鼠I型干扰素（α，β，ω 和τ）。I型干扰素是由白细胞（α亚型），成纤维细胞（β亚型），淋巴细胞（ω亚型）和反刍动物胚胎（τ亚型）产生的165-172个氨基酸蛋白的密切相关家族。该细胞因子具有抗病毒、抗增殖、免疫调节和促炎活性。
外形
磷酸盐缓冲盐水溶液，含有 1 mg/ml牛血清白蛋白。
分析说明
在细胞病变效应抑制试验中，使用含有水泡性口炎病毒（VSV）的MDBK细胞测定生物活性。用1单位/ml干扰素可产生50%的细胞病变效应。单位是根据人干扰素αA的NIH国际标准参考确定的。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves
法规信息
常规特殊物品
含少量动物源组分生物产品
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Antimicrobial agents and chemotherapy, 52(5), 1862-1864 (2008-03-12)
Rapid emergence of resistance to monotherapy with virus-specific inhibitors necessitates combination therapy. ACH-806 is a hepatitis C virus NS4A inhibitor with a novel mechanism of action and resistance pathway. This compound was synergistic with NS3 protease inhibitors and NS5B nucleoside
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