推荐产品
生物来源
human
质量水平
重组
expressed in E. coli
方案
≥95%
表单
buffered aqueous solution
分子量
19 kDa
包装
pkg of 100K units
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
颜色
colorless
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... IFNA2(3440)
应用
已使用人干扰素-αA/D：
- 用于鉴定冠状病毒复制酶抑制剂
- 与ACH-806[1-（4-戊氧基-3-三氟甲基苯基）-3-（吡啶-3-羰基）硫脲]结合以研究对丙型肝炎病毒（HCV）复制的影响
- 与维生素D结合用于检查细胞培养物中HCV蛋白生成的减少
生化/生理作用
干扰素-αA/D（Bg/II），也称为通用I型干扰素，是一种跨越物种屏障的α干扰素杂种。Bg/II表示由重组人干扰素αA和αD构建该杂种的限制性酶切位点。干扰素-αA/D 已被证明对许多哺乳动物细胞具有活性。它可以替代人，猴，小鼠，牛，大鼠，猫，狗，兔，绵羊，山羊，马，猪或仓鼠I型干扰素（α，β，ω 和τ）。I型干扰素是由白细胞（α亚型），成纤维细胞（β亚型），淋巴细胞（ω亚型）和反刍动物胚胎（τ亚型）产生的165-172个氨基酸蛋白的密切相关家族。该细胞因子具有抗病毒、抗增殖、免疫调节和促炎活性。
该细胞因子具有抗病毒、抗增殖、免疫调节和促炎活性。
外形
磷酸盐缓冲盐水溶液，含有 1 mg/ml牛血清白蛋白。
分析说明
在细胞病变效应抑制试验中，使用含有水泡性口炎病毒（VSV）的MDBK细胞测定生物活性。用1单位/ml干扰素可产生50%的细胞病变效应。单位是根据人干扰素αA的NIH国际标准参考确定的。
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves
法规信息
常规特殊物品
含少量动物源组分生物产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Sophie Rogée et al.
Antiviral research, 161, 1-9 (2018-10-28)
Rabies virus transmits from animals to humans and causes encephalitis. Every year more than 15 million people receive a post exposure prophylaxis (PEP) treatment that is highly effective in the prevention of rabies disease. However, when clinical symptoms appear, for
David L Wyles et al.
Antimicrobial agents and chemotherapy, 52(5), 1862-1864 (2008-03-12)
Rapid emergence of resistance to monotherapy with virus-specific inhibitors necessitates combination therapy. ACH-806 is a hepatitis C virus NS4A inhibitor with a novel mechanism of action and resistance pathway. This compound was synergistic with NS3 protease inhibitors and NS5B nucleoside
Julio A Gutierrez et al.
Journal of virology & antiviral research, 3(3), doi:10-doi:10 (2015-11-26)
Previous studies suggest that low serum 25-hydroxyvitamin D [25(OH) D] levels are associated with reduced responsiveness to interferon and ribavirin therapy. We investigated the impact of vitamin D metabolites on HCV and cellular gene expression in cultured hepatoma cells. HCV
Hector Moreno et al.
Viruses, 13(7) (2021-08-11)
The New World (NW) mammarenavirus group includes several zoonotic highly pathogenic viruses, such as Junin (JUNV) or Machupo (MACV). Contrary to the Old World mammarenavirus group, these viruses are not able to completely suppress the innate immune response and trigger
Ronald Dijkman et al.
Journal of virology, 96(11), e0036422-e0036422 (2022-05-20)
Effective broad-spectrum antivirals are critical to prevent and control emerging human coronavirus (hCoV) infections. Despite considerable progress made toward identifying and evaluating several synthetic broad-spectrum antivirals against hCoV infections, a narrow therapeutic window has limited their success. Enhancing the endogenous
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门