推荐产品
生物来源
human
质量水平
重组
expressed in E. coli
方案
≥95%
表单
buffered aqueous solution
分子量
19 kDa
包装
pkg of 20 μg
浓度
≥0.2 mg/mL
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
颜色
colorless
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... IFNA2(3440)
相关类别
应用
人干扰素-αA已被用于：
- 研究基孔肯亚病毒对干扰素介导的JAK（Janus激酶）-STAT（信号转导和转录活化因子）信号的影响
- 研究干扰素-α和PRK2（蛋白激酶C相关激酶2）抑制剂对丙型肝炎病毒复制的影响
- 比较红曲霉色素衍生物对丙型肝炎病毒复制的影响
生化/生理作用
具有抗病毒、抗增殖、免疫调节和促炎活性的细胞因子。
具有抗病毒、抗增殖、免疫调节和促炎活性的细胞因子。I型干扰素是由白细胞（α亚型），成纤维细胞（β亚型），淋巴细胞（ω亚型）和反刍动物胚胎（τ亚型）产生的165-172个氨基酸蛋白的密切相关家族。干扰素可诱导靶细胞产生多种作用，包括抗病毒、抗增殖和免疫调节活性。
外形
以5 mM 乙酸钠，pH 4.0中的溶液形式提供。
分析说明
在细胞病变效应抑制试验中，使用含有水疱性口炎病毒（VSV）的MDBK细胞测定生物活性。用1单位/ml干扰素可产生50%的细胞病变效应。单位是根据WHO人干扰素αA国际标准参考确定的。
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Ji-Min Sun et al.
The Journal of antimicrobial chemotherapy, 67(1), 49-58 (2011-11-15)
Hepatitis C virus (HCV) infection causes chronic liver disease and is a major public health problem worldwide. The aim of this study was to evaluate the potential of Monascus pigment derivatives, which were derived from a microbial secondary metabolite synthesized
S-J Kim et al.
Journal of viral hepatitis, 16(10), 697-704 (2009-02-27)
Hepatitis C virus (HCV) infection is a serious threat to human health worldwide. In spite of the continued search for specific and effective anti-HCV therapies, the rapid emergence of drug-resistance variants has been hampering the development of anti-HCV drugs designed
Jelke J Fros et al.
Journal of virology, 84(20), 10877-10887 (2010-08-06)
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected cells to respond to interferon
Shuai Shao et al.
JCI insight, 6(20) (2021-09-08)
Altered epidermal differentiation along with increased keratinocyte proliferation is a characteristic feature of psoriasis and pityriasis rubra pilaris (PRP). However, despite this large degree of overlapping clinical and histologic features, the molecular signatures these skin disorders share are unknown. Using
A convenient and rapid cytopathic effect inhibition assay for interferon.
P C Familletti et al.
Methods in enzymology, 78(Pt A), 387-394 (1981-01-01)
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