I4276
干扰素-αA 人
≥95%, suitable for cell culture, buffered aqueous solution, recombinant, expressed in E. coli
别名:
IFN-αA, 干扰素-α2A
产品名称
干扰素-αA 人, ≥95%, suitable for cell culture, buffered aqueous solution, recombinant, expressed in E. coli
color
colorless
biological source
human
recombinant
expressed in E. coli
assay
≥95%
form
buffered aqueous solution
mol wt
19 kDa
packaging
pkg of 20 μg
concentration
≥0.2 mg/mL
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
human ... IFNA2(3440)
Analysis Note
在细胞病变效应抑制试验中，使用含有水疱性口炎病毒（VSV）的MDBK细胞测定生物活性。用1单位/ml干扰素可产生50%的细胞病变效应。单位是根据WHO人干扰素αA国际标准参考确定的。
Application
人干扰素-αA已被用于：
- 研究基孔肯亚病毒对干扰素介导的JAK（Janus激酶）-STAT（信号转导和转录活化因子）信号的影响
- 研究干扰素-α和PRK2（蛋白激酶C相关激酶2）抑制剂对丙型肝炎病毒复制的影响
- 比较红曲霉色素衍生物对丙型肝炎病毒复制的影响
Biochem/physiol Actions
具有抗病毒、抗增殖、免疫调节和促炎活性的细胞因子。
具有抗病毒、抗增殖、免疫调节和促炎活性的细胞因子。I型干扰素是由白细胞（α亚型），成纤维细胞（β亚型），淋巴细胞（ω亚型）和反刍动物胚胎（τ亚型）产生的165-172个氨基酸蛋白的密切相关家族。干扰素可诱导靶细胞产生多种作用，包括抗病毒、抗增殖和免疫调节活性。
Physical form
以5 mM 乙酸钠，pH 4.0中的溶液形式提供。
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
法规信息
常规特殊物品
此项目有
S-J Kim et al.
Journal of viral hepatitis, 16(10), 697-704 (2009-02-27)
Hepatitis C virus (HCV) infection is a serious threat to human health worldwide. In spite of the continued search for specific and effective anti-HCV therapies, the rapid emergence of drug-resistance variants has been hampering the development of anti-HCV drugs designed
Jelke J Fros et al.
Journal of virology, 84(20), 10877-10887 (2010-08-06)
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected cells to respond to interferon
Ji-Min Sun et al.
The Journal of antimicrobial chemotherapy, 67(1), 49-58 (2011-11-15)
Hepatitis C virus (HCV) infection causes chronic liver disease and is a major public health problem worldwide. The aim of this study was to evaluate the potential of Monascus pigment derivatives, which were derived from a microbial secondary metabolite synthesized
Shuai Shao et al.
JCI insight, 6(20) (2021-09-08)
Altered epidermal differentiation along with increased keratinocyte proliferation is a characteristic feature of psoriasis and pityriasis rubra pilaris (PRP). However, despite this large degree of overlapping clinical and histologic features, the molecular signatures these skin disorders share are unknown. Using
S Rubinstein et al.
Journal of virology, 37(2), 755-758 (1981-02-01)
A convenient assay for interferons based on reduction of cytopathic effect was developed. The number of manipulations and the lengths of the various incubation steps were reduced to a minimum. The assay is simple to perform and can be completed
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持