I4028
Monoclonal Anti-Interleukin-18 Receptor antibody produced in mouse
clone 70625.111, purified immunoglobulin, lyophilized powder
别名:
Anti-IL-18 Receptor
产品名称
Monoclonal Anti-Interleukin-18 Receptor antibody produced in mouse, clone 70625.111, purified immunoglobulin, lyophilized powder
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
70625.111, monoclonal
form
lyophilized powder
species reactivity
human
technique(s)
flow cytometry: suitable (2.5μg/SUP>106 cell)
immunocytochemistry: 8-25 μg/mL
immunohistochemistry: 8-25 μg/mL
isotype
IgG1
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... IL18R1(8809)
Biochem/physiol Actions
IL-18 belongs to the IL-1 cytokine superfamily and is a regulator of innate and acquired immune responses. The immune responses of IL-18 are mediated by its interaction and subsequent signaling by IL-18 receptor complex. The IL-18R complex is made up of α chain that binds to extracellular IL-18 and a β chain that is involved in signal transduction. The IL-18/IL-18R signaling enhances T and NK cell maturation, cytotoxicity and secretion of cytokines.
General description
The antibody will neutralize the biological activity of recombinant human IL-18 receptor.
Immunogen
recombinant human IL-18 receptor extracellular domain, expressed in NS0 cells.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Preparation Note
Purified using protein G.
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存储类别
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Diana Boraschi et al.
European cytokine network, 17(4), 224-252 (2007-03-14)
IL-18 is among the cytokines responsible for immune-mediated pathologies and is probably one of the factors that contribute to the pathogenesis of autoimmune diseases. Identification of the causes of uncontrolled IL-18 production and activity in autoimmunity would allow for novel
J Alastair Gracie et al.
Journal of leukocyte biology, 73(2), 213-224 (2003-01-30)
Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses. IL-18 is expressed at sites of chronic inflammation, in autoimmune diseases, in a variety of cancers
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