创始人
Sanofi Aventis
质量水平
储存温度
2-8°C
SMILES字符串
CS(O)(=O)=O.CCC(NC(C)C)C(O)c1ccc(O)c(O)c1
InChI
1S/C13H21NO3.CH4O3S/c1-4-10(14-8(2)3)13(17)9-5-6-11(15)12(16)7-9;1-5(2,3)4/h5-8,10,13-17H,4H2,1-3H3;1H3,(H,2,3,4)
InChI key
SOYAGMVKMXZVNZ-UHFFFAOYSA-N
基因信息
human ... ADRB1(153) , ADRB2(154) , ADRB3(155)
应用
Isoetharine mesylate salt has been used:
- as an adrenergic drug to test its effect on embryo implantation in 4-day pregnant mice
- as a substrate for recombinant human sulfotransferase (SULT) in SULT assay to monitor conjugation reaction
- as a β-2 agonist in collision-induced dissociation (CID) mass spectrometry analysis
生化/生理作用
Isoetharine is an agonist for β-adrenergic receptors and is a bronchodilator. It is a catecholic drug metabolized by sulfotransferases and is present in human urine and plasma as a sulfated metabolite. Catechol O-methyltransferase (COMT) also mediates the methylation of isoetharine in the metabolic conjugation pathway.
特点和优势
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Aronson JK
- Pesticide Residues in Food - 1992:
Report of the Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Expert Group on Pesticide Residues, Rome, 21-30 September 1992
(2016)
Gas-phase dissociation pathways of Beta-2 agonists
Carlo MJ, et al.
International Journal of Mass Spectrometry, 463, 116548-116548 (2021)
P Carvalho et al.
Journal of applied physiology (Bethesda, Md. : 1985), 84(1), 215-221 (1998-02-06)
We studied the dose-dependent effects of inhaled isoetharine HCl, a beta-adrenergic bronchodilator (2.5, 5.0, 10.0, and 20.0 mg), on bronchial blood flow (Qbr) in anesthetized sheep. Isoetharine resulted in a dose-dependent increase in Qbr. With a total dose of 17.5
Qi Chen et al.
The Journal of biological chemistry, 286(6), 4349-4356 (2010-12-15)
Pregnancy loss is a serious social and medical issue, with one important cause associated with aberrant embryo implantation during early pregnancy. However, whether and how the process of embryo implantation is affected by environmental factors such as stress-induced sympathetic activation
N B Charan et al.
Journal of applied physiology (Bethesda, Md. : 1985), 82(2), 686-692 (1997-02-01)
In anesthetized sheep, we measured bronchial blood flow (Qbr) by an ultrasonic flow probe to investigate the interaction between inhaled nitric oxide (NO; 100 parts/million) given for 5 min and 5 ml of aerosolized isoetharine (1.49 x 10(-2) M concentration).
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