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安全信息

I3525

Sigma-Aldrich

Interleukin-17A human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

别名:

CTLA-8, IL-17

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About This Item

MDL编号:
MFCD01094096
UNSPSC代码:
12352202
NACRES:
NA.32

生物来源

human

质量水平

100

重组

expressed in E. coli

方案

≥98% (SDS-PAGE)

表单

lyophilized powder

效能

≤2.0 ng/mL ED50

分子量

31 kDa

包装

pkg of 50 μg

技术

cell culture | mammalian: suitable

杂质

endotoxin, tested (endotoxin level is less than 0.1 ng per μg cytokine (1 EU/μg).)

UniProt登记号

Q16552

储存温度

−20°C

基因信息

human ... IL17A(3605)

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生化/生理作用

IL-17, initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.

外形

Lyophilized with no additives.

分析说明

  • The biological activity of human IL-17 is measured by its ability to induce IL-6 production using NHDF cells.
  • Biological activity is also determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblast. The expected ED50 is < 2.0 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
MKCQ3006
MKCP5477
MKCP1640
MKCN5183
MKCN1731

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the solution from which product I3525, Interleukin-17A human recombinant, was prepared?

    Product I3525, Recombinant Human IL-17A, was lyophilized with no additives, which means it was lyophilized from water and may contain trace amounts of 0.1% TFA (pH 2.0) from being HPLC-purified.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Lin Fan et al.
PloS one, 10(5), e0127087-e0127087 (2015-05-29)
Th1 cells play an essential role in immune protection against tuberculosis. Th17 cells might be involved with immune pathology in active human tuberculosis (TB). The balance between Th1 and Th17 cells in patients with cavitary tuberculosis needs to be clarified
Yan Jin et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 52(10), 981-988 (2015-08-25)
There has been significant interest in the association between asthma and the polymorphisms of IL-17A and IL-17F for a period of time. This work aims to present a clearer relationship between asthma and the polymorphisms of IL-17A and IL-17F. Searches
W T Qi et al.
Genetics and molecular research : GMR, 14(4), 13364-13369 (2015-11-05)
We conducted a study to investigate the role of three IL-17 gene single nucleotide polymorphisms (SNP) (rs2275913G>A, rs3748067C>T, and rs763780 T>C) in the development of gastric cancer. A total of 252 patients with gastric cancer and 252 control subjects were
J Y Wang et al.
Allergy, 64(7), 1056-1060 (2009-02-13)
The interleukin 17A (IL17A) gene, located on chromosome 6p and linked to asthma phenotype, is a highly potential candidate gene conferring asthma susceptibility. The purpose of this study was to investigate the genetic association between single nucleotide polymorphisms (SNPs) of
Hye-Lin Ha et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(33), E3422-E3431 (2014-08-06)
Psoriasis is a chronic inflammatory skin disease characterized by abnormal keratinocyte proliferation and differentiation and by an influx of inflammatory cells. The mechanisms underlying psoriasis in humans and in mouse models are poorly understood, although evidence strongly points to crucial
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