推荐产品
生物来源
human
质量水平
重组
expressed in E. coli
方案
≥97% (SDS-PAGE)
表单
lyophilized powder
效能
0.015-0.075 μg/mL ED50 (chemoattract mouse BaF3 cells transfected with hCXCR3)
0.03-0.18 μg/mL ED50 (chemoattract T-Lymphocytes)
分子量
8.7 kDa
包装
pkg of 10 μg
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
human ... CXCL10(3627)
一般描述
The gene for C-X-C motif chemokine ligand 10 (CXCL10), also known as interferon-γ-inducible protein-10 (IP-10), is mapped to human chromosome 4q21.1. IP-10 is secreted by monocytes, neutrophils, endothelial cells, keratinocytes, fibroblasts, mesenchymal cells, dendritic cells, astrocytes and hepatocytes. It is a polypeptide of 78 amino acids. Human IP-10 shows 67% amino acid homology to mouse CRG-2.
生化/生理作用
IP-10 (interferon-γ-inducible protein-10) protein is a proinflammatory chemokine which controls immune responses. It interacts with chemokine receptor 3 (CXCR3) and activates leukocytes including T cells, eosinophils, monocytes and natural killer cells. Mutations in IP-10 are associated with rheumatoid arthritis. In humans with chronic hepatitis C virus (HCV) infection or HCV/human immunodeficiency virus (HIV) co-infection, IP-10 is linked with obesity and insulin resistance.
IP-10, a chemoattractant for activated T lymphocytes, is a potent inhibitor of angiogenesis and displays thymus-dependent anti-tumor effects.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose containing 50 μg bovine serum albumin per 1 μg of cytokine.
分析说明
The biological activity is measured by its ability to chemoattract mouse BaF/3 cells transfected with hCXCR3.
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Daniel Kotrych et al.
Rheumatology international, 35(8), 1319-1323 (2015-02-24)
Chemokines (CXCL) and their receptors play important roles in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to examine the associations between polymorphisms in the CXCL9 (rs3733236 G>A) and CXCL10 (rs8878 A>G) genes and RA. We
Dachao Mo et al.
Genetic testing and molecular biomarkers, 23(12), 837-842 (2019-11-22)
Background: Hashimoto's thyroiditis (HT) is a common autoimmune disease characterized by lymphoid infiltration of the thyroid gland, including both
Chia-Chu Chang et al.
Scientific reports, 5, 10096-10096 (2015-05-12)
Nonalcoholic fatty liver disease (NAFLD) is an important risk factor for the development of type 2 diabetes mellitus. Interferon gamma-induced protein 10 (IP-10), a proinflammatory chemokine, plays a crucial role in inflammatory diseases. This cross-sectional pilot study investigated whether circulating
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