质量水平
检测方案
≥98% (HPLC)
形式
solid
溶解性
DMSO: >20 mg/mL
运输
wet ice
储存温度
−20°C
SMILES字符串
Oc1ccc(Cl)cc1C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F
InChI
1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)
InChI key
CHILCFMQWMQVAL-UHFFFAOYSA-N
应用
IMD-0354 has been used to study the effect of NF-κB (nuclear factor) inhibition on differentially expressed in chondrocytes 2. It has also been used to study the role of NF-κB signaling in tumor necrosis factor-induced certain transcription factors expression using human primary fibroblasts.
生化/生理作用
IMD-0354 acts as an inhibitor by inhibiting the phosphorylation of the NF-κB (nuclear factor) and its translocation into the nucleus. It blocks IκBα phosphorylation (IC50 ~ 250 nM). Cardioprotectant, that reduces IL-1β and MCP-1 production (IC50 < 1 μM) in cardiomyocytes. IMD-0354 affects angiogenesis, which has been observed in human umbilical vein endothelial cells. It prevents tube formation and migration of the cells. In vivo studies also prove that IMD-0354 inhibits retinal vessel growth. IMD-0354 also acts as an inhibitor of Aquaporin 4 (AQP4) inhibitor (IC50 0.2μM) with no inhibitory potency to IKK-β. [4]
包装
Light sensitive. Packaged under nitrogen.
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
Investigating mechanisms of angiogenesis in health and disease using zebrafish models, 24-25 (2018)
Zhen-Yu Ma et al.
Biochemical and biophysical research communications, 471(4), 576-581 (2016-02-14)
Activated fibroblasts continue to proliferate at injury sites, leading to progressive muscular fibrosis in Duchenne muscular dystrophy (DMD). TGF-β1 is a dominant profibrotic mediator thought to play a critical role in muscle fibrosis; however, the implicated mechanisms are not fully
Differentially Expressed in Chondrocytes 2 (DEC2) Increases the Expression of IL-1beta and Is Abundantly Present in Synovial Membrane in Rheumatoid Arthritis
Olkkonen J, et al.
PLoS ONE, 10(12), e0145279-e0145279 (2015)
Cecilia S Vieira et al.
Frontiers in physiology, 9, 1189-1189 (2018-09-21)
Rhodnius prolixus is an insect vector of Trypanosoma cruzi, the causative agent of Chagas disease in Latin America. Nuclear factor-κB (NF-κB) transcription factors (TF) are conserved components of the innate immune system in several multicellular organisms including insects. The drug
Fumihito Hikage et al.
Experimental cell research, 403(1), 112581-112581 (2021-04-04)
To evaluate Nuclear Factor NF-κB (NF-κB) signaling on microglia activation, migration, and angiogenesis in laser-induced choroidal neovascularization (CNV). Nine-week-old C57BL/6 male mice were randomly assigned to IMD-0354 treated or untreated groups (5 mice, 10 eyes per group). CNV was induced
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