生物来源
mouse
质量水平
重组
expressed in E. coli
检测方案
>97% (SDS-PAGE)
形式
lyophilized powder
效能
0.01-1.50 ng/mL EC50
分子量
~18 kDa
包装
pkg of 5 μg
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
mouse ... Il10(16153)
相关类别
应用
来自小鼠的白介素-10已被用作ELISA（酶联免疫吸附测定）细胞因子测定的标准品。
生化/生理作用
白介素-10是淋巴和髓样细胞功能的重要调节剂。IL-10可以阻断细胞因子合成的激活和巨噬细胞的几种辅助功能。人和小鼠IL-10具有73%的序列同源性。然而，人IL-10同时作用于人和小鼠靶细胞，而小鼠IL-10具有物种特异性活性。在小鼠中，IL-10的细胞来源包括Th2细胞，活化的胎儿胸腺细胞，巨噬细胞，角质形成细胞，LY-1+ （CD5+）和正常B细胞。在人类中，IL-10的细胞来源包括CD4+T细胞和T细胞克隆，胸腺细胞，B细胞，B细胞淋巴瘤，巨噬细胞，肥大细胞系和角质形成细胞。IL-10刺激干细胞，肥大细胞和胸腺细胞的生长。IL-10增强细胞毒性T细胞发育并共同刺激B细胞分化和Ig分泌。 IL-10通过诱导血管生成或血管抑制因子的细胞类型依赖性表达来调节血管生成。
白介素-10调节淋巴和髓样细胞功能它阻断细胞因子合成的激活和巨噬细胞的几种辅助功能。IL-10增强细胞毒性T细胞发育并共同刺激B细胞分化和Ig分泌。IL-10通过诱导血管生成或血管抑制因子的细胞类型依赖性表达来调节血管生成。
外形
从PBS中经0.2 μm过滤的溶液pH 7.4中冻干，每1μg含50 μg BSA作为载体蛋白
分析说明
在使用MC/9细胞的细胞增殖测定中测定IL-10的生物活性。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
含少量动物源组分生物产品
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Sergio M Borghi et al.
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What is the central question of this study? This study investigated the role of the endogenous anti-inflammatory cytokine interleukin-10 in intense acute swimming-induced muscle mechanical hyperalgesia in mice. What is the main finding and its importance? Endogenous interleukin-10 has a
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Musculoskeletal injuries induce systemic inflammation which often impairs lung function contributing to morbidity. IL-10 has been shown to have a beneficial effect on immune dysfunction and organ damage after different traumatic insults. We sought to investigate the effect of inhalative
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Fucosylated glycans on the surface of epithelial cells (ECs) regulate intestinal homeostasis by serving as attachment receptors and a nutrient source for some species of bacteria. We show here that epithelial fucosylation in the ileum is negatively regulated by IL-10-producing
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The aim of this study was to evaluate the effects of azilsartan (AZT) on bone loss, inflammation, and the expression of matrix metallo proteinases (MMPs), receptor activator of nuclear factor κB ligand (RANKL), receptor activator of nuclear factor κB (RANK)
商品
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
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