重组
expressed in baculovirus infected Sf9 cells
质量水平
产品线
PRECISIO® Kinase
检测方案
≥70% (SDS-PAGE)
形式
buffered aqueous glycerol solution
比活
378-512 nmol/min·mg
分子量
~81 kDa
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... IRAK4(51135)
生化/生理作用
IRAK4 (interleukin-1 receptor-associated kinase 4) protein contains a death domain and a kinase-like domain. IRAKs are mainly involved in toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs) signaling. IRAK4 can activate NF-κB (nuclear factor κ B) and MAPK (mitogen activated protein kinase) pathways. It plays a crucial role in adaptive immunity and inflammatory responses. IRAK4 mRNA levels are higher in humans suffering from Vogt-Koyanagi-Harada (VKH) disease. Mutations in IRAK4 are associated with recurrent pyogenic bacterial infections in children.
外形
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
法律信息
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
Ryan Ferrao et al.
Molecular cell, 55(6), 891-903 (2014-09-10)
Trans-autophosphorylation is among the most prevalent means of protein kinase activation, yet its molecular basis is poorly defined. In Toll-like receptor and interleukin-1 receptor signaling pathways, the kinase IRAK4 is recruited to the membrane-proximal adaptor MyD88 through death domain (DD)
Min Sun et al.
PloS one, 9(4), e93214-e93214 (2014-04-03)
To explore whether IRAK1 and IRAK4 are involved in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease. Thirty-nine VKH patients and thirty-two healthy controls were included in this study. The mRNA levels of IRAK1 and IRAK4 from active VKH patients, inactive VKH
Shyun Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(8), 5567-5572 (2002-04-18)
Toll/IL-1 receptor family members are central components of host defense mechanisms in a variety of species. One well conserved element in their signal transduction is Ser/Thr kinases, which couple early signaling events in a receptor complex at the plasma membrane
Nobutaka Suzuki et al.
Trends in immunology, 23(10), 503-506 (2002-09-26)
Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns and members of the proinflammatory interleukin-1 receptor (IL-1R) family, share homologies in their cytoplasmic domains. Engagement of members of both of these families initiates a common intracellular signaling cascade, in which MyD88
Leah Cushing et al.
The Journal of biological chemistry, 289(15), 10865-10875 (2014-02-26)
IRAK4 is a central kinase in innate immunity, but the role of its kinase activity is controversial. The mechanism of activation for IRAK4 is currently unknown, and little is known about the role of IRAK4 kinase in cytokine production, particularly
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