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Merck
CN

I2633

Sigma-Aldrich

测心绿

Powder

别名:

吲哚菁绿, 福氏绿, 靛氰绿

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About This Item

经验公式(希尔记法):
C43H47N2NaO6S2
CAS号:
分子量:
774.96
Beilstein:
4115884
EC 号:
MDL编号:
UNSPSC代码:
12171500
PubChem化学物质编号:
NACRES:
NA.47

产品名称

测心绿, polymethine dye

质量水平

表单

powder

组成

Dye content, ≥75%

技术

titration: suitable

颜色

green to very dark green

溶解性

water: 0.01 g/mL

应用

diagnostic assay manufacturing
hematology
histology

储存温度

room temp

SMILES字符串

[Na+].CC1(C)/C(=C\C=C\C=C\C=C\C2=[N+](CCCCS([O-])(=O)=O)c3ccc4ccccc4c3C2(C)C)N(CCCCS([O-])(=O)=O)c5ccc6ccccc6c15

InChI

1S/C43H48N2O6S2.Na/c1-42(2)38(44(28-14-16-30-52(46,47)48)36-26-24-32-18-10-12-20-34(32)40(36)42)22-8-6-5-7-9-23-39-43(3,4)41-35-21-13-11-19-33(35)25-27-37(41)45(39)29-15-17-31-53(49,50)51;/h5-13,18-27H,14-17,28-31H2,1-4H3,(H-,46,47,48,49,50,51);/q;+1/p-1

InChI key

MOFVSTNWEDAEEK-UHFFFAOYSA-M

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一般描述

Cardiogreen是一种带负电荷的聚甲炔染料,可与蛋白质形成非共价荧光复合物。这种“假荧光”特性已被用于进行蛋白测定(通过带有二极管激光诱导荧光检测的毛细管电泳进行测定)。

应用

Cardiogreen已被用于解析几种标记的蛋白质,包括:人血清白蛋白、核糖核酸酶A、转铁蛋白和细胞色素c。
Cardiogreen已被用作眼内囊染色剂。它已用于心输出量的染料稀释法。

包装

无底玻璃瓶。内容物包含在插入的融合锥内。

分析说明

溶解度:0.01g溶于10mL H2O:绿色至深绿色溶液

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. Has Cardiogreen been used for in vivo optical imaging studies?

    We do not subject this product to in vivo testing. However, one study documents the use of the product in a study with mice:For optical imaging, mice were injected intravenously with a mixture of 0.05 ml of 260 μM ICG (Cardiogreen) and 0.05 ml of 360 μM DTR (70,000 MW, Invitrogen) in saline (equivalent to 0.4 mg per kg or 7.4 μM initial concentration in blood).

  7. Does Cardiogreen dissolve equally well in saline and in water?

    Each lot is tested for solubility in hot water at 1 mg/mL. We have found that Sigma Product No. I2633 (which has the same CAS number as Product No. 21980) dissolves in water at 1 mg/mL without heating. Further dilute in saline to prepare an isotonic solution.

  8. How long can I store a solution of Cardiogreen after it has been prepared?

    Sigma-Aldrich recommends that solutions be prepared fresh and not stored. Solutions "are stable only for a few hours and cannot be kept overnight." See: Sigma-Aldrich Handbook of Dyes, Stains, and Indicators, Green, F. ed., p. 407.

  9. Can Product No. I2633, Cardiogreen, be used as a biological stain?

    Limited absorbance in the visible region practically precludes the use of Indocyanine Green as a biological stain. See: Sigma-Aldrich Handbook of Dyes, Stains, and Indicators, Green, F. ed., p. 407.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Aqueous Angiography with Fluorescein and Indocyanine Green in Bovine Eyes.
Huang AS et al.
Translational vision science & technology, 5, 5-5 (2016)
Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acutely hypoxic rats.
Irwin D et al.
American Journal of Respiratory Cell and Molecular Biology, 42, 200-200 (2010)
E M McCorquodale et al.
Electrophoresis, 22(12), 2403-2408 (2001-08-25)
Indocyanine green (ICG)--a negatively charged, polymethine dye--can interact noncovalently with proteins to form fluorescent complexes, with excitation and emission maxima near 780 and 820 nm, respectively. This behavior was realized utilizing either a 100 mM phosphate buffer or a 25
Jun Shibasaki et al.
The Journal of pediatrics, 164(5), 1116-1120 (2014-02-13)
To investigate the use of indocyanine green (ICG) lymphography in the diagnosis and assessment of the severity of lymphatic dysfunction in infants and neonates with congenital lymphatic pleural effusion and ascites. We performed ICG lymphography on 10 neonates and infants
Manuel M Hermann et al.
Ophthalmology, 121(4), 905-910 (2013-12-25)
Intravitreal anti-vascular endothelial growth factor (VEGF) injections are currently the standard treatment for neovascular age-related macular degeneration (AMD), but a broad range of response rates has been observed. We evaluated the association of single nucleotide polymorphisms (SNPs) in VEGF genes

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