I2406
IL-11 human
>97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture
别名:
Interleukin-11 human, IL-11
登录 查看组织和合同定价。
选择尺寸
关于此项目
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf21 cells
Assay:
>97% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
23 kDa
Impurities:
endotoxin, tested
产品名称
Interleukin-11 human, >97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture
biological source
human
recombinant
expressed in baculovirus infected Sf21 cells
assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
0.06-0.24 ng/mL ED50
mol wt
23 kDa
packaging
pkg of 5 μg
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... IL11(3589)
正在寻找类似产品? 访问 产品对比指南
General description
Interleukin-11 (IL-11) is synthesized by many mesenchymal origin cells like keratinocytes, synoviocytes, fibroblasts, bone marrow stromal cells, osteoblasts, and chondrocytes.
The gene IL-11 (interleukin 11) is mapped to human chromosome 19q13.4. It is a secreted protein.
Biochem/physiol Actions
Interleukin 11 (IL-11) is involved in promoting tissue fibrosis and regulates the function of chondrocytes, synoviocytes, and B cells. It is also involved in bone metabolism and tissue remodeling.
Interleukin-11, also called adipogenesis inhibitory factor (AGIF), is a pleotropic cytokine that acts on hematopoietic progenitor cells and stromal cells. Although recombinant human IL-11 has a predicted molecular mass of 19 kDa, it migrates as a 23 kDa band in SDS-PAGE. It is a functional homolog of IL-6, inducing the proliferation of certain plasmacytoma cell lines and acute phase protein secretion in the liver. IL-11 stimulates the production of erythrocytes, megakaryocytes, and T cell development of antibody producing B cells.
Physical form
Lyophilized from a 0.2 μm filtered solution of PBS and EDTA with BSA as a carrier protein.
Analysis Note
The biological activity is measured in a cell proliferation assay using T11, a subline of the IL-6-dependent murine plasmacytoma cell line T1165.85.2.1 that has been adapted to grow in IL-11.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
低风险生物材料
常规特殊物品
此项目有
B Lebeau et al.
FEBS letters, 407(2), 141-147 (1997-04-28)
Long-term stable Ba/F3 transfectants (B13R alpha1 and B13R alpha2) expressing two isoforms of the human IL-IIR alpha receptor (alpha1 full length or alpha2 lacking the cytoplasmic domain) in combination with human gp130 were established. IL-11R alpha1 and IL-11R alpha2 were
S X Leng et al.
The international journal of biochemistry & cell biology, 29(8-9), 1059-1062 (1997-08-01)
Interleukin-11 (IL-11) is an IL-6-type cytokine that is produced by a variety of stromal cells including fibroblasts, epithelial cells and osteoblasts. It binds to a multimeric receptor complex which contains an IL-11-specific alpha subunit and a promiscuous 130 kDa beta
Interleukin-11: a cytokine signaling through gp130 with pleiotropic effects and potential clinical utility within and outside the hematopoietic system.
Jacobsen, S.E.W. et al.
The Cytokine Handbook, 365-365 (1998)
I Kawashima et al.
FEBS letters, 283(2), 199-202 (1991-06-03)
A cDNA encoding a novel adipogenesis inhibitory factor (AGIF) that inhibits the process of adipogenesis in mouse 3T3-L1 preadipocytes was cloned from a cDNA library of the human bone marrow-derived stromal cell line KM-102. The cloned cDNA contains an open
V F Quesniaux et al.
Blood, 80(5), 1218-1223 (1992-09-01)
Interleukin-11 (IL-11), a pleiotropic cytokine originally isolated from a primate bone marrow stromal cell line, has been shown to stimulate T-cell-dependent B-cell maturation, megakaryopoiesis, and various stages of myeloid differentiation, but to inhibit adipogenesis. Because stromal cells are essential for
商品
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
相关内容
Datasheet
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持