I2285
IPA-3
≥95% (HPLC), powder
别名:
1,1′-二(2-羟基-1-萘基)二硫醚
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C20H14O2S2
化学文摘社编号:
分子量:
350.45
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H
SMILES string
Oc1ccc2ccccc2c1SSc3c(O)ccc4ccccc34
InChI key
RFAXLXKIAKIUDT-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
powder
color
off-white to yellow
solubility
DMSO: >20 mg/mL, H2O: insoluble
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
IPA-3是Pak1的变构抑制剂。
IPA-3是Pak1的变构抑制剂。它与pak1（p21激活激酶）的自身抑制结构域结合，在激酶中具有高选择性。 Pak1与肿瘤发生和转移有关。
signalword
Danger
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Elena G Sánchez et al.
PLoS pathogens, 8(6), e1002754-e1002754 (2012-06-22)
African swine fever (ASF) is caused by a large and highly pathogenic DNA virus, African swine fever virus (ASFV), which provokes severe economic losses and expansion threats. Presently, no specific protection or vaccine against ASF is available, despite the high
Aniruddha Das et al.
Scientific reports, 7(1), 13930-13930 (2017-10-27)
Fear conditioning, a behavioral model for studying fear-related disorders, is believed to be formed by alterations of synaptic efficacy mediated by changes in synaptic transmission and neuronal morphology in lateral amygdala (LA). Rac GTPase and its downstream effector p21-activated kinase (PAK)
Karla C Williams et al.
Oncogene, 38(19), 3598-3615 (2019-01-18)
Invadopodia are cell protrusions that mediate cancer cell extravasation but the microenvironmental cues and signaling factors that induce invadopodia formation during extravasation remain unclear. Using intravital imaging and loss of function experiments, we determined invadopodia contain receptors involved in chemotaxis
Elaine Y Chung et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(12), 3589-3601 (2019-03-14)
To evaluate therapeutic activity of PAK inhibition in ATLL and to characterize the role of PAK isoforms in cell proliferation, survival, and adhesion of ATLL cells in preclinical models. Frequency and prognostic impact of PAK2 amplification were evaluated in an
Mathilde Gavillet et al.
American journal of hematology, 93(2), 269-276 (2017-11-11)
NET formation in mice (NETosis) is supported by reactive oxygen species (ROS) production by NADPH oxidase and histone hypercitrullination by peptidylarginine deiminase 4 (PAD4). Rac1 and Rac2, expressed in polymorphonuclear neutrophils (PMNs), regulate the cytoskeleton, cell shape, adhesion, and migration
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持