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选择尺寸
关于此项目
经验公式(希尔记法):
C38H35N5O6S2
化学文摘社编号:
分子量:
721.84
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
KN-62, ≥95%, powder
InChI
1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1
SMILES string
O=S(OC1=CC=C(C[C@@H](C(N2CCN(C3=CC=CC=C3)CC2)=O)N(C)S(C4=CC=CC5=C4C=CN=C5)(=O)=O)C=C1)(C6=CC=CC7=C6C=CN=C7)=O
InChI key
RJVLFQBBRSMWHX-DHUJRADRSA-N
biological source
synthetic (organic)
assay
≥95%
form
powder
color
yellow
mp
130 °C
solubility
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL
methanol: 10 mg/mL
DMSO: 12 mg/mL
chloroform: 20 mg/mL
storage temp.
−20°C
Quality Level
Gene Information
human ... P2RX7(5027)
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相关类别
Biochem/physiol Actions
选择性抑制大鼠脑 Ca2+/钙调蛋白依赖性蛋白激酶 II。
Features and Benefits
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Katoh Shinsuke et al.
Journal of radiation research, 58(6), 809-815 (2017-11-07)
Chronic irradiation with low-dose-rate 137Cs-γ rays inhibits the differentiation of human neural progenitor cells and influences the expression of proteins associated with several cellular functions. We aimed to determine whether such chronic irradiation influences the expression of proteins associated with
Ana B Ramos-Hryb et al.
Pharmacological reports : PR, 69(6), 1240-1246 (2017-11-13)
Ursolic acid has been shown to display antidepressant-like effects in mice through the modulation of monoaminergic systems. In this study, we sought to investigate the involvement of signaling pathways on the antidepressant-like effects of ursolic acid. Mice were treated orally
R J MacLeod et al.
The Journal of membrane biology, 172(1), 59-66 (1999-11-07)
To assess the activation of the charybdotoxin-insensitive K(+) channel responsible for Regulatory Volume Decrease (RVD) after substantial volume increases, we measured intracellular pH (pH(i)), intracellular calcium ([Ca(2+)](i)) and inhibitors of kinases and phosphoprotein phosphatases in guinea pig jejunal villus enterocytes
Safina Gadeock et al.
Biochimica et biophysica acta, 1798(11), 2058-2066 (2010-07-31)
The P2X7 receptor is an extracellular ATP-gated cation channel critical in inflammation and immunity, and can be up-regulated by IFN-γ and LPS. This study aimed to examine the effect of TGF-β1 on the up-regulation of P2X7 function and expression in
Nikki Jo-Hao Weng et al.
Stem cell research, 23, 39-49 (2017-07-04)
New methods are needed to reduce dynamic blebbing which inhibits cell attachment and survival during passaging of pluripotent stem cells. We tested the hypothesis that activation of the P2X7 receptor by extracellular ATP during passaging initiates dynamic blebbing. The P2X7
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