所有图片(1)
别名:
R(+)-[(6,7-二氯-2-环戊基-2,3-二氢-2-甲基-1-氧代-1H-茚满-5-基)-氧]乙酸, R(+)-甲基吲唑酮, 茚满基含氧乙酸 94
经验公式（希尔记法）:
C17H18Cl2O4
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质量水平
检测方案
≥98% (HPLC)
形式
solid
旋光性
[α]22/D +36.4°, c = 0.86 in methanol(lit.)
颜色
white
溶解性
H2O: 0.2 mg/mL
0.1 M NaOH: 2.8 mg/mL
DMSO: >20 mg/mL
ethanol: 20 mg/mL
dilute aqueous acid: insoluble
储存温度
2-8°C
SMILES字符串
C[C@@]1(Cc2cc(OCC(O)=O)c(Cl)c(Cl)c2C1=O)C3CCCC3
InChI
1S/C17H18Cl2O4/c1-17(10-4-2-3-5-10)7-9-6-11(23-8-12(20)21)14(18)15(19)13(9)16(17)22/h6,10H,2-5,7-8H2,1H3,(H,20,21)/t17-/m1/s1
InChI key
RNOJGTHBMJBOSP-QGZVFWFLSA-N
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
D W Landry et al.
The Journal of general physiology, 90(6), 779-798 (1987-12-01)
Chloride channels are present in the majority of epithelial cells, where they mediate absorption or secretion of NaCl. Although the absorptive and secretory channels are well characterized in terms of their electrophysiological behavior, there is a lack of pharmacological ligands
Human THP-1 monocyte uptake and cellular disposition of 14C-grepafloxacin
Hall I H, et al.
Journal of Infection and Chemotherapy, 10(1), 11-18 (2004)
Michelle Batthish et al.
Cardiovascular research, 55(3), 660-671 (2002-08-06)
We have recently proposed that chloride (Cl(-)) channels contribute to ischemic preconditioning (IPC) in the myocardium. To further evaluate this hypothesis, we investigated the role of Cl(-) channels in pharmacological preconditioning. Isolated rabbit cardiomyocytes and isolated buffer-perfused rabbit hearts were
Disposition and intracellular levels of moxifloxacin in human THP-1 monocytes in unstimulated and stimulated conditions
Hall I H, et al.
International Journal of Antimicrobial Agents, 22(6), 579-587 (2003)
Influence of T-type Ca2+ (mibefradil) and Cl- (indanyloxyacetic acid 94) channel antagonists on ?1-adrenoceptor mediated contractions in rat aorta.
Duggan AJ and Tabrizchi R
Canadian Journal of Physiology and Pharmacology, 78(9), 714-720 (2000)
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