生物来源
human
质量水平
重组
expressed in NSO cells
检测方案
>97% (SDS-PAGE)
形式
lyophilized powder
分子量
36 kDa
包装
pkg of 0.1 mg
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
human ... IL1R1(3554)
一般描述
Interleukin-1 type 1 receptor (IL1R1) is a glycoprotein. It is mainly expressed on endothelial cells, epithelial cells, hepatocytes, fibroblasts, epidermal dendritic cells as well as T lymphocytes.
生化/生理作用
Interleukin-1 (IL-1), a cytokine, is a key regulator of acute and chronic inflammation. The IL-1 associated responses are achieved by association of IL-1 with IL-1 type 1 receptor (IL1R1).
Recombinant human IL-1 soluble receptor I is a transmembrane protein and a member of the immunoglobulin superfamily. It is expressed predominantly by T cells, fibroblasts, and endothelial cells.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5.0 mg bovine serum albumin
分析说明
The bioactivity is measured by its ability to inhibit the IL-1β-dependent proliferation of a murine helper T cell line, D10.G4.1.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
含少量动物源组分生物产品
常规特殊物品
F F Vasilyev et al.
Cellular & molecular immunology, 12(2), 222-230 (2014-07-01)
The biological activity of the multifunctional cytokine interleukin-1 (IL-1) is mediated by its receptors. The aim of this study was to determine if an association exists between single nucleotide polymorphisms (SNPs) in the IL-1 type 1 and 2 receptor genes
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