所有图片(1)
别名:
N-（6-甲基-2-苯并噻唑基）-2-[（3,4,6,7-四氢-4-氧代-3-苯基噻吩并[3,2-d] 嘧啶-2-基）硫代]-乙酰胺
经验公式（希尔记法）:
C22H18N4O2S3
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质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
溶解性
DMSO: 2 mg/mL, clear (warmed)
储存温度
room temp
SMILES字符串
Cc1ccc2nc(NC(=O)CSC3=NC4=C(SCC4)C(=O)N3c5ccccc5)sc2c1
InChI
1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)
InChI key
WRKPZSMRWPJJDH-UHFFFAOYSA-N
应用
IWP-2已用于处理L-Wnt-3a和L-Wnt-5a细胞系以证明其抑制作用。它还作为Wnt信号抑制剂用于处理WT和Gja1Jrt/+基质、细胞，以确认Wnt/β-连环蛋白信号通路与Gja1Jrt/+成骨细胞的标志物表达增加无关。
生化/生理作用
IWP-2 是 Porcn 功能的失活剂；Wnt 生成抑制剂。Wnt/β-catenin（“经典”）通路维持转录程序，使干细胞保持多能。Wnt/β-catenin 通路的过度激活导致疾病分期。IWP-2 抑制 Wnt 生成。IWP 可能通过直接抑制 Porcn 活性部位或通过调节 Porcn 调节器的功能而使 Porcn 功能失活。Porcn 是膜结合型 O-酰基转移酶 (MBOAT) 家族的一员，该家族为 Wnt 蛋白增加了一个棕榈酰基，该基团对其信号传导能力至关重要，是 Wnt 分泌所必需的。IWP-2 在再生医学和抗癌努力中都是有作用。
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Farhana Islam et al.
Behavioural brain research, 326, 217-225 (2017-03-13)
The mechanisms by which dopaminergic neurotransmission in the nucleus accumbens (NAc) is involved in incentive learning produced by rewarding stimuli remain unclear. Recently, Wnt signalling has been implicated in synaptic plasticity and learning and memory. Functional interactions between Wnt and
Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-beta (A-beta) 42 peptides
Tapia-Rojas C, et al.
Journal of Neurochemistry, 139(6), 1175-1191 (2016)
Wenwen Liu et al.
Antioxidants & redox signaling, 30(11), 1389-1410 (2018-03-29)
Cisplatin can damage spiral ganglion neurons (SGNs) and cause sensorineural hearing loss. Wnt activation protects against neomycin-induced hair cell damage in the mouse cochlea, but the role of Wnt signaling in protecting SGNs from cisplatin treatment has not yet been
Francis Grafton et al.
eLife, 10 (2021-08-03)
Drug-induced cardiotoxicity and hepatotoxicity are major causes of drug attrition. To decrease late-stage drug attrition, pharmaceutical and biotechnology industries need to establish biologically relevant models that use phenotypic screening to detect drug-induced toxicity in vitro. In this study, we sought
Ruitao Zhang et al.
Journal of experimental & clinical cancer research : CR, 38(1), 494-494 (2019-12-18)
Downregulation of microRNA-338-3p (miR-338-3p) was detected in many malignant tumors, which indicated miR-338-3p might serve as a role of antioncogene in those cancers. The present study aimed to explore the roles of miR-338-3p in the growth and metastasis of ovarian
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