I0523
IL-2 mouse
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
别名:
mIL-2, IL-2, T细胞生长因子
产品名称
白细胞介素-2 来源于小鼠, IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
biological source
mouse
recombinant
expressed in E. coli
assay
≥97% (SDS-PAGE)
form
lyophilized powder
potency
≤0.2 ng/mL ED50
quality
endotoxin tested
mol wt
17.2 kDa
packaging
pkg of 5X20 μg
pkg of 20 μg
technique(s)
cell culture | mammalian: suitable
impurities
≤1.000 EU/μg
color
white
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
mouse ... Il2(16183)
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Analysis Note
通过对鼠CTLL-2细胞进行剂量依赖性刺激来测定活性。 ED50： ≤ 0.2 ng/ml（相当于5 × 106 单位/mg的比活度）
Application
来自小鼠的白介素-2已被用于诱导大鼠模型的败血症。 它还被用于树突状表皮T细胞培养。
Biochem/physiol Actions
白细胞介素2（IL-2）是由T淋巴细胞的某些亚群产生的免疫调节因子。该淋巴因子可促进活化T细胞和相关细胞类型的长期生长。IL-2在自然杀伤细胞的激活和增殖中发挥作用、诱导γ-干扰素和B细胞生长因子的分泌，并调节IL-2受体的表达。已知IL-2表达会随着年龄的增长而降低，并导致流感病毒感染、肿瘤和致死性自身免疫。IL-2参与T细胞的增殖和分化，并控制T细胞的稳态。作为免疫应答的一部分，IL-2能够刺激辅助性T细胞1和2以及骨骼肌的内皮白细胞。IL-2调节受到c-rel蛋白的控制。IL-2是一种神经营养分子，在皮层、海马、中隔、小脑和视网膜神经元中具有特殊功能。
General description
IL-2（白介素2）编码促炎性细胞因子。 IL-2主要在辅助性T细胞中表达。
Physical form
从 0.2 μm 过滤的 10mM 柠檬酸钠溶液 (pH 4.0) 中冻干。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
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Gong Z, et al.
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Protein kinases JAK and ERK mediate protective effect of interleukin-2 upon ganglion cells of the developing rat retina
Marra C, et al.
Journal of Neuroimmunology, 233(1-2), 120-126 (2011)
Krithika Badarinath et al.
Methods in molecular biology (Clifton, N.J.), 1879, 285-297 (2018-06-14)
The interplay of immune cells and stem cells in maintaining skin homeostasis and repair is an exciting new frontier in cutaneous biology. With the growing appreciation of the importance of this new crosstalk comes the requirement of methods to interrogate
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Studena S, et al.
Biological & Pharmaceutical Bulletin, 35(10), 1703-1710 (2012)
商品
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
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