推荐产品
产品名称
IWR-1, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear
储存温度
room temp
SMILES字符串
O=C(Nc1cccc2cccnc12)c3ccc(cc3)N4C(=O)[C@@H]5[C@H]6C[C@H](C=C6)[C@@H]5C4=O
InChI
1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,20-21H,13H2,(H,27,29)/t16-,17+,20-,21+
InChI key
ZGSXEXBYLJIOGF-ALFLXDJESA-N
应用
IWR-1已被用作人类胚胎干细胞（hESCs）、小鼠lewis肺癌（LLC）和Sepia胚胎中Wingless/Integrated（WNT）信号通路的拮抗剂。
生化/生理作用
IWR-1是一种端锚聚合酶抑制剂，其对癌症干细胞样细胞具有细胞毒性。它可抑制 体内 骨肉瘤的进展。IWR-1可与RNA聚合酶II相互作用，对于预启动复合物的形成至关重要。
Wnt/b-连环蛋白（‘经典′）途径维持转录程序，使干细胞保持多能性。Wnt/b-连环蛋白途径超活化会导致疾病分期。IWR-3充当Wnt反应的抑制剂。似乎IWR化合物通过直接相互作用诱导Axin蛋白稳定化，该蛋白是b-连环蛋白破坏复合体（由Apc、Axin、Ck1和Gsk3b组成）的一部分。
特点和优势
该化合物是基因调控研究的推荐产品。点击此处，了解更多推荐基因调控产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问sigma.com/discover-bsm。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Jessica E Frith et al.
PloS one, 8(12), e82931-e82931 (2014-01-01)
Cellular microenvironmental conditions coordinate to regulate stem cell populations and their differentiation. Mesenchymal precursor cells (MPCs), which have significant potential for a wide range of therapeutic applications, can be expanded or differentiated into osteo- chondro- and adipogenic lineages. The ability
IWR-1, a tankyrase inhibitor, attenuates Wntbeta-catenin signaling in cancer stem-like cells and inhibits in vivo the growth of a subcutaneous human osteosarcoma xenograft
Martins-Neves SR, et al.
Cancer Letters, 414, 1-15 (2018)
Efficient differentiation of TBX18+/WT1+ epicardial-like cells from human pluripotent stem cells using small molecular compounds
Zhao J, et al.
Stem Cells and Development, 26(7), 528-540 (2017)
A serine in exon 11 determines the full transcriptional activity of TCF-4 in lung carcinoma cells
Yang B, et al.
Biochemical and biophysical research communications, 508(3), 675-681 (2019)
Fei Gao et al.
Cancer letters, 402, 177-189 (2017-06-13)
Akt1 is essential for the oncogenic transformation and tumor growth in various cancers. However, the precise role of Akt1 in advanced cancers is conflicting. Using a neuroendocrine TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model, we first show that the
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