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质量水平
方案
≥98% (HPLC)
表单
powder
旋光性
[α]/D +73 to +84°, c = 0.5 in water
颜色
white to beige
溶解性
H2O: >5 mg/mL
抗生素抗菌谱
mycobacteria
作用机制
cell wall synthesis | interferes
创始人
Merck & Co., Inc., Kenilworth, NJ, U.S.
储存温度
−20°C
SMILES字符串
O.C[C@@H](O)[C@@H]1[C@H]2CC(SCCNC=N)=C(N2C1=O)C(O)=O
InChI
1S/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1
InChI key
GSOSVVULSKVSLQ-JJVRHELESA-N
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一般描述
Chemical structure: ß-lactam
应用
Imipenem monohydrate has been used to determine the resistance profiles of Pseudomonas aeruginosa isolates. It has also been used in susceptibility testing against Acinetobacter baumannii.
生化/生理作用
亚胺培南一水合物是广谱 B -内酰胺抗生素。 它是碳青霉烯类“魔弹”抗生素的一种,用于严重感染。
Imipenem is found effective against gram positive and negative aerobes and anaerobes. Imipenem is often combined with cilastatin, to inhibit its metabolism in kidney.
特点和优势
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
从最新的版本中选择一种:
分析证书(COA)
Journal of medical microbiology, 62(Pt 9), 1343-1349 (2013-06-07)
The objective of this study was to investigate the susceptibility of hospital-associated (HA) and community-associated (CA) Escherichia coli and Klebsiella pneumoniae isolated from patients with intra-abdominal infections (IAIs) in China. From 2002 to 2011, the minimum inhibitory concentrations (MICs) of
Could plazomicin alone or in combination be a therapeutical option against carbapenem-resistant Acinetobacter baumannii?
Antimicrobial agents and chemotherapy, AAC-00873 (2015)
Efficacy of imipenem/cilastatin in endocarditis
The American Journal of Medicine, 78(6), 117-121 (1985)
Acta crystallographica. Section D, Biological crystallography, 69(Pt 9), 1697-1706 (2013-09-04)
The modelling of peptidoglycan is responsible for key cellular processes in Mycobacterium tuberculosis such as cell growth, division and resuscitation from dormancy. The structure of M. tuberculosis peptidoglycan is atypical since it contains a majority of 3,3 cross-links synthesized by L,D-transpeptidases
Could plazomicin alone or in combination be a therapeutical option against carbapenem-resistant Acinetobacter baumannii?
Antimicrobial Agents and Chemotherapy, AAC-00873 (2015)
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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