所有图片(1)
别名:
Primaxin 一水合物, Tienam 一水合物, （5R，6S）-6-[（（1R）-1-羟基乙基] -3-[[2-[（亚氨基甲基）氨基]乙基]硫代] -7-氧代-1-氮杂双环[3.2.0] hept-2 -烯-2-羧酸 一水合物
经验公式（希尔记法）:
C12H17N3O4S · H2O
CAS号:
分子量:
317.36
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
检测方案
≥98% (HPLC)
形式
powder
旋光性
[α]/D +73 to +84°, c = 0.5 in water
颜色
white to beige
溶解性
H2O: >5 mg/mL
抗生素抗菌谱
mycobacteria
作用机制
cell wall synthesis | interferes
创始人
Merck & Co., Inc., Kenilworth, NJ, U.S.
储存温度
−20°C
SMILES字符串
O.C[C@@H](O)[C@@H]1[C@H]2CC(SCCNC=N)=C(N2C1=O)C(O)=O
InChI
1S/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1
InChI key
GSOSVVULSKVSLQ-JJVRHELESA-N
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一般描述
Chemical structure: ß-lactam
应用
Imipenem monohydrate has been used to determine the resistance profiles of Pseudomonas aeruginosa isolates. It has also been used in susceptibility testing against Acinetobacter baumannii.
生化/生理作用
亚胺培南一水合物是广谱 B -内酰胺抗生素。 它是碳青霉烯类“魔弹”抗生素的一种，用于严重感染。
Imipenem is found effective against gram positive and negative aerobes and anaerobes. Imipenem is often combined with cilastatin, to inhibit its metabolism in kidney.
特点和优势
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
Investigation of the chemical composition and different effects of a Rumex dentatus methanol extract against drug resistant pseudomonas aeruginosa Isolates
Najafabadi MP, et al.
Iranian Red Crescent Medical Journal, 18(12) (2016)
Antibiotic and chemotherapy e-book, 234-234 (2010)
Florence Suy et al.
Journal of clinical microbiology, 51(9), 3147-3150 (2013-07-05)
We report Campylobacter fetus meningitis associated with endocarditis in a 75-year-old diabetic man after he consumed raw liver. C. fetus was isolated from blood samples and cerebrospinal fluid. Cure was obtained with combined intravenous imipenem-gentamicin for 4 weeks; no relapse
Could plazomicin alone or in combination be a therapeutical option against carbapenem-resistant Acinetobacter baumannii?
Garcia Salguero C, et al.
Antimicrobial Agents and Chemotherapy, AAC-00873 (2015)
Qiwen Yang et al.
Journal of medical microbiology, 62(Pt 9), 1343-1349 (2013-06-07)
The objective of this study was to investigate the susceptibility of hospital-associated (HA) and community-associated (CA) Escherichia coli and Klebsiella pneumoniae isolated from patients with intra-abdominal infections (IAIs) in China. From 2002 to 2011, the minimum inhibitory concentrations (MICs) of
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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