Anti-TLE3 antibody produced in rabbit

Transducin-like enhancer of split 3 (TLE3) belongs to the groucho family and comprises Q and WD40 domains. The TLE3 gene is mapped to human chromosome locus 15q23. It is expressed in adipocytes and shows higher levels in white adipose tissue (WAT) than the brown adipose tissue (BAT). It is also expressed in the prostate. TLE3 exists in isoforms due to alternative splice events.

transducin-like enhancer of split 3

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Transducin-like enhancer of split 3 (TLE3) acts as a modulator of adipogenesis. It is a transcriptional integrator for the nuclear receptor, peroxisome proliferator-activated receptor γ (PPARγ). TLE3 also interacts with Notch and controls the differentiation of epithelial cells. It serves as a transcriptional repressor for adenomatous polyposis coli (APC) and β-catenin in the wingless (Wnt) pathway by its interaction with the chromatin complex. TLE3 mediates inhibition of mitochondrial gene expression and early B-cell factor (EBF2) in beige adipocytes and regulates thermogenic gene expression. It may serve as a therapeutic target for obesity and diabetes.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST85538

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

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