Anti-PTPRK antibody produced in rabbit

PTPRK (receptor-type protein tyrosine phosphatase kappa) plays an important role in angiogenesis. It participates in cell proliferation, adhesion and tubule formation. It represses cell migration, especially, the migration induced by FGF (fibroblast growth factor). PTPRK dephosphorylates epidermal growth factor receptor (EGFR) and affects the activities of EGFR in primary human keratinocytes. Overexpression of PTPRK represses EGFR tyrosine phosphorylation and prevents cell growth.

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

PTPRK (receptor-type protein tyrosine phosphatase kappa) codes for RPTPκ. It is a member of the transmembrane PTP subfamily. PTPRK has a Meprin-A5-protein PTPμ domain, an immunoglobulin-like domain and four fibronectin III-type repeats and an intracellular region containing a juxtamembrane region and two PTP domains. This gene is located on human chromosome 6q22.33.

protein tyrosine phosphatase, receptor type, K

Corresponding Antigen APREST91501

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

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