生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
产品线
Prestige Antibodies® Powered by Atlas Antibodies
形式
buffered aqueous glycerol solution
种属反应性
human
技术
immunohistochemistry: 1:50- 1:200
免疫原序列
AGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENTDLTCRQPKCDKCNAAYPHLAHLPSAMADSSFRFPRTWWQSAEDVHRE
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... NTN4(59277)
一般描述
NTN4 (netrin-4) belongs to the axon guidance molecule family. It is expressed in the inner lamina II (lamina IIi) neurons of the dorsal horn. It is located on chromosome 12q22.
免疫原
netrin 4 recombinant protein epitope signature tag (PrEST)
应用
Anti-NTN4 antibody has been used in immunohistochemistry.
生化/生理作用
NTN4 (netrin-4) is responsible for increasing the mechanical and thermal sensitivity throughout neuropathic or inflammatory pain. It is actively involved in angiogenesis, lung branching, and salivary gland formation.
特点和优势
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
联系
Corresponding Antigen APREST85291
外形
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
法律信息
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B.
Hayano Y, et al.
The Journal of Experimental Medicine, 213(13), 2949-2966 (2016)
Lars Harbaum et al.
American journal of respiratory and critical care medicine, 205(12), 1449-1460 (2022-04-09)
Rationale: Pulmonary arterial hypertension (PAH) is characterized by structural remodeling of pulmonary arteries and arterioles. Underlying biological processes are likely reflected in a perturbation of circulating proteins. Objectives: To quantify and analyze the plasma proteome of patients with PAH using
Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer.
Lyng H, et al.
BMC Genomics, 7:268 (2006)
Netrin-4 regulates thalamocortical axon branching in an activity-dependent fashion.
Hayano Y, et al.
Proceedings of the National Academy of Sciences of the USA, 111(42), 15226-15231 (2014)
Xavier Farré et al.
ERJ open research, 8(1) (2022-01-28)
Lymphangioleiomyomatosis (LAM) is a rare low-grade metastasising disease characterised by cystic lung destruction. The genetic basis of LAM remains incompletely determined, and the disease cell-of-origin is uncertain. We analysed the possibility of a shared genetic basis between LAM and cancer
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