Anti-HSD3B1 antibody produced in rabbit

3 β-hydroxysteroid dehydrogenase/delta 5->4-isomerase type 1 (HSD3B1) is a key enzyme essential for the formation of steroid sex hormones. It is majorly expressed in mammary glands, prostate, placenta and sebaceous glands of skin. HSD3B1 gene is mapped to human chromosome 1p12 and has four exons.

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

3 β-hydroxysteroid dehydrogenase/delta 5->4-isomerase type 1 (HSD3B1) catalyses the conversion of steroid dehydroepiandrosterone sulfate to estrogen precursors hormones. It regulates levels of dihydrotestosterone (DHT). HSD3B1 is highly expressed in breast cancer and HSD3B1 gene knockdown results in tumor growth inhibition. A single nucleotide polymorphism in the HSD3B1 gene enhances enzyme activity and improves dihydrotestosterone (DHT) production in castration-resistant prostate cancer (CRPC). Expression of HSD3B1 is downregulated in ovarian cancer. Polymorphism in HSD3B1 is implicated in individuals with hypertension.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST82530

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

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