抗-ANKRD1 兔抗

The ankyrin repeat domain 1 (ANKRD1) gene mapped to human 10q23.33, encodes cardiac adriamycin responsive protein (CARP). The encoded nuclear protein is a member of the muscle ankyrin repeat proteins family. Members of this family contain four ankyrin repeats constituting a conserved motif. ANKRD1 is mainly expressed in heart during embryonic and fetal development.

ankyrin repeat domain 1 (cardiac muscle) recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Ankyrin repeat domain 1 (ANKRD1) might act as a transcriptional negative regulator for Ventricular myosin light chain-2 (MLC-2v) in cardiac myogenesis. The encoded protein plays a vital role in cardiac muscle function in both physiological and pathological conditions. Additionally, it is also implicated in the regulation of gene expression in the heart. Variations in the gene expression leads to hypertrophic cardiomyopathy (HCM) and human dilated cardiomyopathy. ANKRD1 functions as a transcriptional co-activator and enhances tumor suppressive activity of p53 protein.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST80281

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

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