Anti-SIK1 antibody produced in rabbit

Serine/threonine-protein kinase (SIK1) also called salt-inducible kinase 1 or sucrose nonfermented 1-like kinase is a serine/threonine kinase. SIK has an N-terminal kinase domain, a central ubiquitin-associated (UBA) domain. SIK1 is mapped to human chromosome 21q22.3.

salt-inducible kinase 1

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Anti-SIK1 antibody produced in rabbit has been used in the detection of SIK1 protein in human tumor samples using immunohistochemistry.

Serine/threonine-protein kinase (SIK1) interacts with mothers against decapentaplegic homolog 7 (SMAD7) and regulates transforming growth factor β (TGFβ) signalling. SIK1 is associated with tuning of circadian rhythms. SIK1 modulates intracellular sodium levels by coordinating with Na⁺,K⁺-ATPase. Mutations in the SIK1 gene is implicated in epilepsy disorder. A truncated SIK1 protein contributes to developmental epilepsy.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST87281

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

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