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Merck
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安全信息

HPA034669

Sigma-Aldrich

抗-LBH 兔抗

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

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别名:
Lbh Antibody, Lbh Antibody - Anti-LBH antibody produced in rabbit, Anti-limb bud and heart development homolog (mouse)
UNSPSC代码:
12352203
人类蛋白质图谱编号:
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

产品线

Prestige Antibodies® Powered by Atlas Antibodies

形式

buffered aqueous glycerol solution

种属反应性

human

技术

immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:200-1:500

免疫原序列

PDYLRSAKMTEVMMNTQPMEEIGLSPRKDGLSYQIFPDPSDFDRCCKLKDRLPSIVVEPTEGEVESGELRWPPEEFLVQEDEQDNCEETAKE

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... LBH(81606)

一般描述

The limb-bud and heart (LBH) gene is mapped to human chromosome 2p23.1. It is mostly expressed in embryonic tissues. LBH is also found in spleen, brain, kidney, gut and peripheral nervous system.

免疫原

limb bud and heart development homolog (mouse) recombinant protein epitope signature tag (PrEST)

应用

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)

生化/生理作用

Limb-bud and heart (LBH) is a transcription cofactor participating in embryogenesis. It mediates the development of limbs and heart in vertebrates. LBH is might be associated with breast cancer via the WNT signaling pathway. It is also known to be involved in cardiac and skeletal abnormalities.

特点和优势

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST79257

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

法律信息

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

法规信息

常规特殊物品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

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访问文档库

Huizhan Liu et al.
Journal of cell science, 134(7) (2021-03-07)
Hearing loss affects ∼10% of adults worldwide. Most sensorineural hearing loss is caused by the progressive loss of mechanosensitive hair cells (HCs) in the cochlea. The molecular mechanisms underlying HC maintenance and loss remain poorly understood. LBH, a transcription co-factor
Elevated limb-bud and heart development (LBH) expression indicates poor prognosis and promotes gastric cancer cell proliferation and invasion via upregulating Integrin/FAK/Akt pathway
Yu R, et al.
PeerJ, 7(11), e6885-e6885 (2019)
Limb-Bud and heart attenuates growth and invasion of human lung adenocarcinoma cells and predicts survival outcome
Deng M, et al.
Cellular Physiology and Biochemistry, 47(1), 223-234 (2018)
LBH gene transcription regulation by the interplay of an enhancer risk allele and DNA methylation in rheumatoid arthritis
Hammaker D, et al.
Arthritis and Rheumatism, 68(11), 2637-2645 (2016)
Yi Li et al.
PloS one, 11(3), e0151291-e0151291 (2016-03-15)
Regulation of gene expression is essential to determining the functional complexity and morphological diversity seen among different cells. Transcriptional regulation is a crucial step in gene expression regulation because the genetic information is directly read from DNA by sequence-specific transcription

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