生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
产品线
Prestige Antibodies® Powered by Atlas Antibodies
表单
buffered aqueous glycerol solution
种属反应性
mouse, human, rat
增强验证
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
技术
immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:1000-1:2500
免疫原序列
RTDFQQGCAKTLYHSVHEKIFTLPGDCLIYPAHDYHGFTVSTVEEERTLNPRLTLSCEEFVKIMGNLNLPKPQQIDFAVPANMRCG
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ETHE1(23474)
一般描述
ETHE1 (persulfide/sulfur dioxygenase) is a member of metallo-β-lactamase superfamily. It codes for a β-lactamase–like, iron-coordinating metalloprotein. It consists of a mononuclear iron in its active site. In eukaryotes, it is found within the mitochondrial matrix.
免疫原
ethylmalonic encephalopathy 1 recombinant protein epitope signature tag (PrEST)
应用
Anti-ETHE1 antibody produced in rabbit has been used in western blotting.
生化/生理作用
ETHE1 (persulfide/sulfur dioxygenase) participates in the catabolism of sulfide that accumulates to toxic levels in ethylmalonic encephalopathy. ETHE1 can transform persulfides to sulfite in the mitochondrial sulfide oxidation pathway. Mutations in ETHE1 cause ethylmalonic encephalopathy.
特点和优势
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
联系
Corresponding Antigen APREST77869
外形
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
法律信息
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome.
EMBO Molecular Medicine, 9(1), 78-95 (2017)
Spectroscopic studies on Arabidopsis ETHE1, a glyoxalase II-like protein.
Holdorf MM, et al.
Journal of Inorganic Biochemistry, 102(9), 1825-1830 (2008)
Pilar González-García et al.
Human molecular genetics, 29(19), 3296-3311 (2020-09-26)
Abnormalities of one carbon, glutathione and sulfide metabolisms have recently emerged as novel pathomechanisms in diseases with mitochondrial dysfunction. However, the mechanisms underlying these abnormalities are not clear. Also, we recently showed that sulfide oxidation is impaired in Coenzyme Q10
Characterization of patient mutations in human persulfide dioxygenase (ETHE1) involved in H2S catabolism.
Kabil O and Banerjee R
The Journal of Biological Chemistry, 287(53), 44561-44567 (2012)
Valeria Tiranti et al.
Nature medicine, 15(2), 200-205 (2009-01-13)
Ethylmalonic encephalopathy is an autosomal recessive, invariably fatal disorder characterized by early-onset encephalopathy, microangiopathy, chronic diarrhea, defective cytochrome c oxidase (COX) in muscle and brain, high concentrations of C4 and C5 acylcarnitines in blood and high excretion of ethylmalonic acid
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