Anti-POLH antibody produced in rabbit

DNA polymerase η is a member of Y family of specialized DNA polymerases, encoded by skin cancer susceptibly gene POLH or XPV (xeroderma pigmentosum variant), mapped to human chromosome band 6p21.1-6p12. The gene with 11 exons, spanning whole coding sequence, does not contain TATA sequence in the upstream region of the transcription-initiation. DNA polymerase η is a human homologue of the yeast Rad30 protein and it belongs to the damage-bypass replication protein family.

polymerase (DNA directed), eta recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

DNA polymerase η (polη) catalyzes an accurate trans-lesion DNA synthesis, suggesting that the XPV (xeroderma pigmentosum variant) gene encoding this protein has a role in tumor suppression in normal individuals. Mutation in this DNA polymerase leads to an inherited disorder called Xeroderma pigmentosum variant (XP-V). DNA polymerase η plays a vital role in repairing UV-induced DNA damage by replacing the major UV-induced lesion with two adenines. DNA polymerase η facilitates hypermutation of immunoglobulin variable genes.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST71087

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

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