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HPA023370

抗PCM1 兔抗

Name: 抗PCM1 兔抗
Brand: SIGMA

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1

别名:

抗PCM-1, 抗hPCM-1, 抗中心粒周物质1蛋白

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所有图片(10)

About This Item

UNSPSC代码:

12352203

人类蛋白质图谱编号:

HPA023370

NACRES:

NA.41

产品HPA023370监管中，请联系销售询价或购买联系客户支持

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此商品	WHA99152504	WHA99142504	WHA99132502
WHA99132504 Whatman^® UNIFLO^® 25 syringe filters	WHA99152504 Whatman^® UNIFLO^® 25 syringe filters	WHA99142504 Whatman^® UNIFLO^® 25 syringe filters	WHA99132502 Whatman^® UNIFLO^® 25 syringe filters
pore size 0.45 μm	pore size 0.45 μm	pore size 0.45 μm	pore size 0.22 μm
diam. 25 mm	diam. 25 mm	diam. 25 mm	diam. 25 mm
material PVDF membrane, polypropylene housing	material polyethersulfone membrane, polypropylene housing	material polyethersulfone membrane, polypropylene housing	material PVDF membrane, polypropylene housing
fitting female inlet fitting for Luer Lock, male outlet fitting for Slip Luer	fitting female inlet fitting for Luer Lock, male outlet fitting for Slip Luer	fitting female inlet fitting for Luer Lock, male outlet fitting for Slip Luer	fitting female inlet fitting for Luer Lock, male outlet fitting for Slip Luer
sterility sterile	sterility sterile	sterility sterile	sterility sterile

一般描述

基因PCM1（中心周围物质1）定位于人类染色体8p22。编码的蛋白质定位于被称为“中心粒卫星”的细胞质颗粒，存在于中心体周围。它具有摩尔质量为228kD的蛋白质。

免疫原

中心粒周物质1蛋白重组蛋白表位信号标签（PrEST）

应用

兔产生的抗PCM1抗体已用于免疫荧光技术中的一抗。[1]它还被用于免疫组织化学[2]研究以及流式细胞术和磁性辅助细胞分选试验。[3]
由Atlas Antibodies提供技术支持的所有Prestige Antibodies^®抗体均由人类蛋白质图集（HPA）项目开发和验证。每种抗体都通过针对数百种正常和疾病组织的免疫组织化学进行测试。通过单击图像库链接，可以在人类蛋白质图谱（HPA）站点上查看这些图像。我们还提供Prestige Antibodies^® 抗体的实验方案和其他有用信息。

生化/生理作用

PCM1基因（中心粒外周物质1）编码带有多个卷曲螺旋结构域的大型中心体蛋白，该蛋白形成一种精神分裂症破坏蛋白1（disrupted-in-schizophrenia 1，DISC1）和巴尔得–别德尔综合征4蛋白（Bardet-Biedl syndrome 4，BBS4）的复合物。这种结合有助于PCM1和其它运送蛋白的协同靶向运输至中心体。它可作为支架材料，并促进多种蛋白以动力蛋白依赖性方式靶向运输至中心体，还有助于调节微管动力学。含有PCM1 蛋白的中心粒卫星（centriolar satellite）参与微管和动力蛋白激活蛋白依赖性蛋白质募集，进入中心体，它还介导中心体蛋白的组装和微管组织。该基因的缺陷与眼灰质体积减少和精神分裂症的易感性有关。

特点和优势

Prestige抗体^®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige抗体对其他蛋白质的独特性和低交叉反应性^®是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。针对每一个Prestige 抗体都存在有对应的Prestige抗原对照，并可在链接区域内找到。

每个Prestige抗体都是按照以下方法进行测试的：

44例正常人类组织以及20例最常见癌症类型组织的IHC组织阵列。
364个人类重组蛋白片段的蛋白阵列。

联系

相应抗原APREST76187

外形

溶于含有40％甘油和0.02％叠氮化钠的的磷酸盐缓冲盐缓冲液（pH7.2）中

法律信息

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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储存分类代码

10 - Combustible liquids

WGK

WGK 1

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

000007184

A104540

R11478

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Noelia Muñoz-Martín et al.

Development (Cambridge, England), 146(3) (2019-01-16)

Myc is considered an essential transcription factor for heart development, but cardiac defects have only been studied in global Myc loss-of-function models. Here, we eliminated Myc by recombining a Myc floxed allele with the Nkx2.5Cre driver. We observed no anatomical

Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo.

Ralf Gilsbach et al.

Nature communications, 9(1), 391-391 (2018-01-28)

Epigenetic mechanisms and transcription factor networks essential for differentiation of cardiac myocytes have been uncovered. However, reshaping of the epigenome of these terminally differentiated cells during fetal development, postnatal maturation, and in disease remains unknown. Here, we investigate the dynamics

Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease.

Ralf Gilsbach et al.

Nature communications, 5, 5288-5288 (2014-10-23)

The heart is a highly specialized organ with essential function for the organism throughout life. The significance of DNA methylation in shaping the phenotype of the heart remains only partially known. Here we generate and analyse DNA methylomes from highly

The effect of resistance training, detraining and retraining on muscle strength and power, myofibre size, satellite cells and myonuclei in older men.

Sara Blocquiaux et al.

Experimental gerontology, 133, 110860-110860 (2020-02-06)

Ageing is associated with an attenuated hypertrophic response to resistance training and periods of training interruptions. Hence, elderly would benefit from the 'muscle memory' effects of resistance training on muscle strength and mass during detraining and retraining. As the underlying

Identification of atrial fibrillation associated genes and functional non-coding variants.

Antoinette F van Ouwerkerk et al.

Nature communications, 10(1), 4755-4755 (2019-10-20)

Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of transcription regulatory elements and target gene expression. To uncover causal genetic variants, variant regulatory elements and their target genes, here

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安全信息

抗PCM1 兔抗