Anti-SH3GLB1 antibody produced in rabbit

SH3GLB1 (SH3-domain GRB2-like endophilin B1) is a pro-apoptotic Bax binding protein belonging to the endophilin B family. It consists of an N-BAR (Bin/Amphiphysin/Rvs) domain with lipid binding ability and a C-terminal SH3 domain with proline-rich region binding capacity.

Endophilin-B1 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

SH3GLB1 (SH3-domain GRB2-like endophilin B1) is a tumor suppressor gene associated with several activities such apoptosis, autophagy, and mitochondrial morphology. It also functions in the endocytic degradation of EGFR (epidermal growth factor receptor) and chemotactic migration in breast cancer cells. Deficiency of SH3GLB1 leads to suppressed programmed cell death and promotes tumorigenesis. It also delays EGFR degradation and sustains Erk1/2 activation in response to EGF stimulation. In breast cancer cells, it promotes EGFR degradation by regulating endosome maturation.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST72561

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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