Anti-HCN1 antibody produced in rabbit

The gene HCN1 (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1) is mapped to human chromosome 5p12. The protein contains transmembrane domains and a carboxy-terminal cyclic nucleotide-binding domain. HCN1 is strongly expressed in the plasma membrane of neurons and is also present in particular compartments (inner segments of photoreceptors, stereocilia of cochlear hair cells).

hyperpolarization activated cyclic nucleotide-gated potassium channel 1 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

HCN (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel) channels get activated by hyperpolarization and can be modulated by cyclic-AMP. They cause cationic ′I_h′ current in neurons, resulting in neuronal excitability and signal transmission in the nervous system. HCN channels mainly carry inward currents of K⁺ and Na⁺. Mutations in HCN1 are linked with early infantile epileptic encephalopathy.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST72946

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

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