Anti-P4HB antibody produced in rabbit

The gene prolyl 4-hydroxylase subunit β (P4HB) is mapped to human chromosome 17q25. It belongs to the family of soluble oxidoreductases. The protein is present at the cell surface of B cells, platelets, pancreatic cells and hepatocytes. The protein localizes in the endoplasmic reticulum and at the cell surface. P4HB is also called as PDI (protein disulfide isomerase).

Protein disulfide-isomerase Precursor recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Prolyl 4-hydroxylase subunit β (P4HB) is involved in the formation of disulfide bonds. In addition, it binds polypeptide chains and work as a chaperone, thereby helping in folding of polypeptides. It also works as a subunit of prolyl 4-hydroxylase (P4H). Impairment in disulfide isomerase activity of P4HB is associated with Cole-Carpenter syndrome. Single nucleotide polymorphism in P4HB is associated with amyotrophic lateral sclerosis. P4HB is up-regulated in presence of hypoxia in astrocytes. It works together with ubiquilin in protecting neurons against apoptosis.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST84449

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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