Anti-DHX58 antibody produced in rabbit

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All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

DHX58 (Probable ATP-dependent RNA helicase) regulates antiviral innate immunity response. DHX58 acts as a dominant-negative regulator of RIG-I (RNA helicase)/MDA5 (melanoma differentiation-associated gene 5)-mediated signaling for innate antiviral responses. On the other hand, evidences also suggest DHX58 role as a positive regulator of antiviral responses. DHX58 helps in MDA5-RNA interactions which lead to heightened MDA5-mediated antiviral signaling.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

The gene DHX58 (Probable ATP-dependent RNA helicase) is mapped to human chromosome 17q21.2. It belongs to the RIG-I (RNA helicase)-like receptor family of proteins. DHX58 generally accumulates in response to viral infection. It is popularly called as LGP2 (laboratory of genetics and physiology 2).

Probable ATP-dependent RNA helicase DHX58 recombinant protein epitope signature tag (PrEST)

Corresponding Antigen APREST74626

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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