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Clone:
polyclonal
Species reactivity:
human
Application:
ChIP
immunofluorescence
immunohistochemistry
immunofluorescence
immunohistochemistry
Technique(s):
ChIP: 1—10 μg (per reaction)
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:200-1:500
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:200-1:500
Citations:
13
Uniprot accession no.:
产品名称
抗-FOS 兔抗, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
Quality Level
Gene Information
human ... FOS(2353)
technique(s)
ChIP: 1—10 μg (per reaction)
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:200-1:500
immunogen sequence
DLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDL
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Physical form
磷酸盐缓冲盐水溶液,pH 7.2,含有40%甘油和0.02%叠氮化钠
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Application
兔抗FOS抗体,属Prestige抗体,由人类蛋白质图谱(HPA)项目开发和验证。每种抗体都通过针对数百种正常和疾病组织的免疫组织化学进行测试。通过单击图像库链接,可以在人类蛋白质图谱(HPA)站点上查看这些图像。还采用免疫荧光和蛋白质印迹法对抗体进行检测。想要查看有关Prestige 抗体和HPA的方案和其他实用信息,请访问 sigma.com/prestige。
由Atlas Antibodies提供技术支持的所有Prestige Antibodies抗体均由人类蛋白质图集(HPA)项目开发和验证,因此受到业内最广泛的表征支持。
人类蛋白质图集项目可以分为三大部分: 人体组织图谱、癌症图谱和人类细胞图谱。在组织和癌症图谱项目支持下产生的抗体已通过对数百种正常和疾病组织的免疫组织化学分析得到了验证,并且通过近期人类细胞图谱项目的努力,许多抗体已经过免疫荧光分析的表征,从而绘制人类蛋白质组图谱,不仅是在组织水平上,现在已经达到亚细胞水平。在人类蛋白质图集项目网站上单击图像库链接,可以查看这些图像和庞大的数据集。我们还提供Prestige Antibodies® 抗体的实验方案和其他有用信息。
人类蛋白质图集项目可以分为三大部分: 人体组织图谱、癌症图谱和人类细胞图谱。在组织和癌症图谱项目支持下产生的抗体已通过对数百种正常和疾病组织的免疫组织化学分析得到了验证,并且通过近期人类细胞图谱项目的努力,许多抗体已经过免疫荧光分析的表征,从而绘制人类蛋白质组图谱,不仅是在组织水平上,现在已经达到亚细胞水平。在人类蛋白质图集项目网站上单击图像库链接,可以查看这些图像和庞大的数据集。我们还提供Prestige Antibodies® 抗体的实验方案和其他有用信息。
Biochem/physiol Actions
C-FOS(细胞癌基因fos)被认为是即早基因。其表达通常较低,但响应于细胞外刺激而迅速增加,从而导致细胞过程,例如细胞增殖和分化。C-FOS与C-JUN(原癌基因C-JUN)形成AP-1(激活蛋白-1)异二聚体复合物,从而充当转录调节因子。C-FOS调节对肿瘤发生很重要的基因。C-FOS表达的变化与精神病倾向或精神分裂症有关。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
Prestige Antibodies®是经过高度表征和广泛验证的抗体,同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige Antibodies®对其他蛋白质的独特性和低交叉反应性是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。每种Prestige 抗体都有相应的Prestige 抗原对照品,可在链接部分找到。
每种Prestige 抗体的检测方法如下:
每种Prestige 抗体的检测方法如下:
- 44种正常人体组织和20种最常见癌症组织的IHC组织阵列。
- 364个人重组蛋白片段的蛋白阵列。
General description
基因C-FOS(细胞癌基因fos)定位于人类染色体14q24.3。属于转录因子AP-1(激活蛋白-1)家族。蛋白主要定位于细胞核内。
Immunogen
原癌基因蛋白c-fos重组蛋白表位信号标签(PrEST)
Other Notes
相应抗原APREST70428
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
常规特殊物品
此项目有
L L Bonnycastle et al.
Neuroscience letters, 160(1), 33-36 (1993-09-17)
A gene for early-onset familial Alzheimer's disease (FAD) is located on chromosome 14q24.3. The c-fos gene (FOS) is also located in the same band of this chromosome and is thus a candidate for the FAD locus. A yeast artificial chromosome
Chu-Chu Qi et al.
Behavioral and brain functions : BBF, 14(1), 7-7 (2018-03-21)
Following a social defeat, the balanced establishment and extinction of aversive information is a beneficial strategy for individual survival. Abnormal establishment or extinction is implicated in the development of mental disorders. This study investigated the time course of the establishment
P Grant et al.
European psychiatry : the journal of the Association of European Psychiatrists, 29(5), 304-306 (2014-03-19)
Psychosis-proneness or schizotypy is a personality organisation mirroring individual risk for schizophrenia-development. Believed to be a fully dimensional construct sharing considerable geno- and phenotypal variance with clinical schizophrenia, it has become an increasingly promising tool for basic psychosis-research. Although many
M M Portal et al.
Oncogene, 26(24), 3551-3558 (2006-12-13)
c-Fos dephosphorylated on tyrosine (c-Fos), a component of the activator protein-1 (AP-1) family of transcription factors, is expressed at very low levels in resting cells. However, its expression is rapidly upregulated in cells undergoing G(0) to S phase transition leading
Guillaume Bossis et al.
Molecular and cellular biology, 25(16), 6964-6979 (2005-08-02)
The inducible transcriptional complex AP-1, composed of c-Fos and c-Jun proteins, is crucial for cell adaptation to many environmental changes. While its mechanisms of activation have been extensively studied, how its activity is restrained is poorly understood. We report here
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Prestige Antibodies Immunofluorescence Procedure
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