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Merck
CN
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文件

安全信息

HPA017980

Sigma-Aldrich

Anti-SLC3A2 antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

别名:

Anti-4F2, Anti-4F2HC, Anti-4T2HC, Anti-CD98, Anti-solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2

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About This Item

UNSPSC代码:
12352203
人类蛋白质图谱编号:
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

产品线

Prestige Antibodies® Powered by Atlas Antibodies

形式

buffered aqueous glycerol solution

种属反应性

human

增强验证

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

技术

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:1000-1:2500

免疫原序列

KGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDL

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... SLC3A2(6520)

一般描述

SLC3A2 (solute carrier family 3 member 2) is an integrin associated protein expressed at high levels on proliferating lymphocytes and other rapidly growing cells. It is also known as CD98hc and 4F2hc. It belongs to the CD98 family. SLC3A2 has a common glycosylated 80 kDa heavy chain and a group of ∼45 kDa light chains. SLC3A2 is located on human chromosome 11q12.

免疫原

solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-SLC3A2 antibody produced in rabbit has been used in western blotting.

生化/生理作用

SLC3A2 (solute carrier family 3 member 2) promotes integrin signalling. It has the ability to modulate the activities of selected integrins (5-8). It also controls the expression and supply of the light chains to regulate amino acid transport function. Absence of CD98hc results in embryonic lethality.

特点和优势

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST72200

外形

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

法律信息

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

分析证书(COA)

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访问文档库

Refinement of the" Silver syndrome locus" on chromosome 11q12-q14 in four families and exclusion of eight candidate genes.
Windpassinger C, et al.
Human Genetics, 114(1), 99-109 (2003)
CD98hc (SLC3A2) interaction with β1 integrins is required for transformation.
Henderson NC, et al.
The Journal of Biological Chemistry, 279(52), 54731-54741 (2004)
Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes.
Lane DJ, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(9), 2793-2813 (2018)
The multifunctional solute carrier 3A2 (SLC3A2) confers a poor prognosis in the highly proliferative breast cancer subtypes.
El Ansari R, et al.
British Journal of Cancer, 118(8), 1115-1115 (2018)
Rokaya El Ansari et al.
British journal of cancer, 118(8), 1115-1122 (2018-03-17)
Breast cancer (BC) is a heterogeneous disease characterised by variant biology, metabolic activity and patient outcome. This study aimed to evaluate the biological and prognostic value of the membrane solute carrier, SLC3A2 in BC with emphasis on the intrinsic molecular

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